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CASE REPORT article

Front. Med.
Sec. Rheumatology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1482350

MDA5-positive dermatomyositis without muscle weakness and rash: A case report and literature review

Provisionally accepted
Ping Ping Xiao Ping Ping Xiao *Wei Fan Wei Fan Xuyan Chen Xuyan Chen Ke-Cong Li Ke-Cong Li Ting-Ting Li Ting-Ting Li Zhigao Dong Zhigao Dong
  • Second Affiliated Hospital of Xiamen Medical College, Xiamen, China

The final, formatted version of the article will be published soon.

    Melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is a rare systemic autoimmune disease associated with a high rate of mortality attributable to rapidly progressive interstitial lung disease. MDA5-positive DM is often complicated by a typical rash and muscle weakness. Herein, we describe a 50-year-old woman who presented with worsening pulmonary symptoms with an absence of typical clinical characteristics. We also review the treatments and prognosis made in similar cases, highlighting that closer attention should be paid to patients presenting with atypical DM, particularly when clinical manifestations such as rash and muscle weakness are not apparent.

    Keywords: melanoma differentiation-associated gene 5, Dermatomyositis, Interstitial Lung Disease, interferon, case report

    Received: 30 Aug 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Xiao, Fan, Chen, Li, Li and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ping Ping Xiao, Second Affiliated Hospital of Xiamen Medical College, Xiamen, China

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