AUTHOR=Wang Zhongjie , Hülpüsch Claudia , Traidl-Hoffmann Claudia , Reiger Matthias , Schloter Michael 

TITLE=Understanding the role of Staphylococcus aureus in atopic dermatitis: strain diversity, microevolution, and prophage influences

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1480257

DOI=10.3389/fmed.2024.1480257

ISSN=2296-858X

ABSTRACT=<p>Atopic dermatitis (AD) is a prevalent inflammatory skin disorder characterized by chronic inflammation, skin barrier dysfunction, and microbial dysbiosis, with <italic>Staphylococcus aureus</italic> playing a significant role in its pathogenesis. This paper explores the strain diversity and microevolution of <italic>S. aureus</italic> within AD patients, emphasizing how specific strains adapt to the altered skin environment, exacerbating the condition. The review emphasizes the significance of variation in specific functional genes among <italic>S. aureus</italic> strains, which enhances their ability to adapt to different microenvironments and shapes their pathogenic potential. It also discusses how mobile genetic elements, particularly prophages, contribute to genetic diversity and drive the virulence and antibiotic resistance of <italic>S. aureus</italic> in AD, highlighting the clinical challenges posed by these strain-specific factors in managing the disease. The paper advocates for the integration of advanced genomic tools such as whole-genome sequencing and machine learning to develop targeted therapies. By focusing on the genetic adaptability of <italic>S. aureus</italic> and its impact on AD, this review underscores the need for strain-specific diagnostics and personalized treatment strategies to improve patient outcomes.</p>