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ORIGINAL RESEARCH article

Front. Med.
Sec. Obstetrics and Gynecology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1478907

Relationship of maternal pre-pregnancy BMI and neonatal birth weight in gestational diabetes mellitus : A retrospective cohort study

Provisionally accepted
Qiuping Liao Qiuping Liao 1,2,3*Tiantian Yu Tiantian Yu 1,2,3Jiajia Chen Jiajia Chen 1,2,3Xiuqiong Zheng Xiuqiong Zheng 1,2,3*Lianghui Zheng Lianghui Zheng 1,2,3*Jianying Yan Jianying Yan 1,2,3*
  • 1 College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, China
  • 2 Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, China
  • 3 National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, China

The final, formatted version of the article will be published soon.

    The aim of this study was to explore the association between maternal pre-pregnancy body mass index(BMI)and neonatal birth weight in pregnancy with GDM.This was a retrospective cohort study between January 2019 and June 2020, based in a university hospital in Fuzhou, China.Results: Pre-pregnancy BMI was used to categorise the 791 pregnant women as underweight(3.03%), normal weight(51.71%), overweight(32.74%) and obesity(12.52%). There were 11.63%, 77.37% and 11.00% of 791 babies with Small-for-gestational-age (SGA), normal weight and large-for-gestational-age infants (LGA), respectively. The rates of SGA babies were gradually rising along with the increased pre-pregnant BMI. The LGA babies percent were higher in women with overweight and obesity compared with normal-weight women. Neonatal birth weight displayed a significantly increasing trend as the maternal pre-pregnancy BMI increasing when the maternal pre-pregnancy BMI was less than 27.78 kg/m 2 (β=0.03, 95%CI [0.01, 0.04]; P=0.0052<0.05), when the maternal pre-pregnancy BMI was greater than 27.78 kg/m 2 the neonatal birth weight decreased as the maternal pre-pregnancy BMI increased (β=-0.01, 95% CI [-0.04, 0.01]; P=0.3555).Conclusions: SGA and LGA babies were more frequent in pre-pregnant overweight/obesity in GDM. The data obtained would offer new view that different management strategies should be implemented for pregnant women with a pre-pregnancy BMI below 27.78 kg/m 2 and those above 27.78 kg/m 2 , especially in GDM. These findings are beneficial for providing information, preconception counselling and health education on weight management for GDM pregnancies.

    Keywords: GDM, Neonatal birth weight, Pre-pregnancy BMI, small for gestational age, large for gestational age

    Received: 11 Aug 2024; Accepted: 10 Dec 2024.

    Copyright: © 2024 Liao, Yu, Chen, Zheng, Zheng and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiuping Liao, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, China
    Xiuqiong Zheng, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, China
    Lianghui Zheng, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, China
    Jianying Yan, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University Fujian Maternity and Child Health Hospital, Fuzhou, China

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