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ORIGINAL RESEARCH article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1478090

Relationship between triglyceride glucose-body mass index and coronary artery calcium score in maintenance hemodialysis patients

Provisionally accepted
泽希 蒋 泽希 蒋 1,2Jinhua Zhu Jinhua Zhu 3Hong Ding Hong Ding 3Lihong Yan Lihong Yan 1,2Ruoxin Chen Ruoxin Chen 1,2Bin Wang Bin Wang 1,2*Zuo-Lin Li Zuo-Lin Li 1,2*Hong Liu Hong Liu 1,2*
  • 1 Southeast University, Nanjing, China
  • 2 Zhongda Hospital, Southeast University, Nanjing, Jiangsu Province, China
  • 3 Institute of Nephrology, People's Hospital of Yangzhong city, Zhenjiang, China

The final, formatted version of the article will be published soon.

    Background: This study investigated the association between coronary artery calcification (CAC) and triglyceride glucose-body mass index (TyG-BMI) in patients receiving maintenance hemodialysis (MHD).We used computed tomography (CT) to assess coronary artery calcification score (CACS) using the Agatston method. The TyG index was multiplied by BMI to derive the TyG-BMI index. Ordinal logistic regression models were used to analyze the relationship between TyG-BMI and CAC. The dose-response relationship was evaluated using restricted cubic spline regression. Weighted Quantile Sum regression was used to explore the weight of the TyG-BMI index components.Results: Based on the TyG-BMI, 219 patients with MHD were stratified into three groups. The TyG-BMI index was shown to be an independent risk factor for CACS by multivariate ordinal logistic regression analysis (odds ratio, 1.011; [95% confidence interval, 1.002-1.021]; P = 0.021). The relationship between TyG-BMI and lg (CACS+10) was linear (P-overall = 0.023, P-nonlinear = 0.412). Body mass index (BMI) had the highest weight (0.566) when weights were assigned to the three components of TyG-BMI. In the non-diabetes and diabetes subgroups, TYG-BMI and lg (CACS+10) did not exhibit a significant nonlinear relationship.Conclusions: TyG-BMI and CAC were independently positively correlated in patients undergoing MHD. These findings suggest that assessing TyG-BMI as a valuable tool for identifying the risk of CAC in patients with MHD.

    Keywords: Triglyceride glucose-body mass index, Coronary artery calcification, cardiovascular disease, Maintenance hemodialysis, Insulin Resistance

    Received: 09 Aug 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 蒋, Zhu, Ding, Yan, Chen, Wang, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bin Wang, Southeast University, Nanjing, China
    Zuo-Lin Li, Southeast University, Nanjing, China
    Hong Liu, Southeast University, Nanjing, China

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