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REVIEW article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1476242
This article is part of the Research Topic Personalized Therapy in ARDS - Volume II View all 5 articles
Reevaluating Vitamin C in Sepsis and Septic Shock: A Potential Benefit in Severe Cases?
Provisionally accepted- 1 Pharmaceutical Care, King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
- 2 College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
- 3 King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabi, Riyadh, Saudi Arabia
- 4 King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia
Vitamin C (Ascorbic acid) has evolved as an emergent co-intervention for sepsis and septic shock patients. Multiple studies discussed the pathophysiological value of vitamin C to reserve endothelial functionality and improve microcirculatory flow in these patients. Nevertheless, most randomized clinical trials failed to show the clinical impact of adding vitamin C to sepsis and septic shock. Pneumonia is the most common infection to induce sepsis and septic shock, which could be an acute respiratory distress syndrome. Preliminary in-vitro data support the role of vitamin C in mitigating the risk of acute respiratory distress syndrome (ARDS) development.This review aims to compare and contrast these trials and explore differences in their patients' populations, methodologies, and outcomes, emphasizing pneumonia-induced sepsis and septic shock.
Keywords: vitamin C, Ascorbic Acid, Sepsis, septic shock, Critically ill, Pneumonia
Received: 05 Aug 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Alissa, Alrashed, Alshaya, Al Sulaiman and Al Harbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mohammed Alrashed, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
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