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REVIEW article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1476242
This article is part of the Research Topic Personalized Therapy in ARDS - Volume II View all 5 articles

Reevaluating Vitamin C in Sepsis and Septic Shock: A Potential Benefit in Severe Cases?

Provisionally accepted
Abdulrahman Alissa Abdulrahman Alissa 1Mohammed Alrashed Mohammed Alrashed 2,3,4*Abdulrahman Alshaya Abdulrahman Alshaya 2,3,4Khalid Al Sulaiman Khalid Al Sulaiman 2,3Shmeylan Al Harbi Shmeylan Al Harbi 2,3,4
  • 1 Pharmaceutical Care, King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia, Riyadh, Saudi Arabia
  • 2 College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
  • 3 King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabi, Riyadh, Saudi Arabia
  • 4 King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    Vitamin C (Ascorbic acid) has evolved as an emergent co-intervention for sepsis and septic shock patients. Multiple studies discussed the pathophysiological value of vitamin C to reserve endothelial functionality and improve microcirculatory flow in these patients. Nevertheless, most randomized clinical trials failed to show the clinical impact of adding vitamin C to sepsis and septic shock. Pneumonia is the most common infection to induce sepsis and septic shock, which could be an acute respiratory distress syndrome. Preliminary in-vitro data support the role of vitamin C in mitigating the risk of acute respiratory distress syndrome (ARDS) development.This review aims to compare and contrast these trials and explore differences in their patients' populations, methodologies, and outcomes, emphasizing pneumonia-induced sepsis and septic shock.

    Keywords: vitamin C, Ascorbic Acid, Sepsis, septic shock, Critically ill, Pneumonia

    Received: 05 Aug 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Alissa, Alrashed, Alshaya, Al Sulaiman and Al Harbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mohammed Alrashed, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.