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ORIGINAL RESEARCH article

Front. Med.
Sec. Dermatology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1475117

Elevated Hematologic Ratios are Correlated with Acne Severity: A National, Retrospective Cohort Study

Provisionally accepted
Vered Wiesel Vered Wiesel 1Sarah Weissmann Sarah Weissmann 1,2Bracha Cohen Bracha Cohen 2Inbal Golan-Tripto Inbal Golan-Tripto 1,3Amir Horev Amir Horev 1,4*
  • 1 Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
  • 2 Soroka Clinical Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
  • 3 Pediatric Pulmonary Unit, Soroka University Medical Center, Beer Sheva, Israel;, Beer Sheva, Israel
  • 4 Pediatric Dermatology Service, Soroka University Medical Center, Beer-Sheva, Israel., Beer-Sheva, Israel

The final, formatted version of the article will be published soon.

    Background: Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity. Methods: National, retrospective cohort study of 122,822 patients using medical records from 2005-2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization. Results: Moderate-severe acne patients had higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) than mild acne patients at diagnosis and 12-18 months before diagnosis. A multivariable regression confirmed the significance of the correlation of increased NLR and PLR with acne severity. Adults and females had higher NLR and PLR than children and males, respectively, at diagnosis, and 12-18 months before diagnosis. Conclusion: Acne severity was significantly associated with elevated NLR and PLR. NLR and PLR may also serve as indicators of upcoming acne severity, as they were elevated 12-18 months before diagnosis. These biomarkers may contribute to the diagnosis, management, and follow-up of patients with acne.

    Keywords: Acne Vulgaris, hematologic ratios, NLR, PLR, Acne, ELR, ENR

    Received: 02 Aug 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Wiesel, Weissmann, Cohen, Golan-Tripto and Horev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Amir Horev, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, 84105, Israel

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.