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ORIGINAL RESEARCH article

Front. Med.
Sec. Rheumatology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1470855

PREVALENCE AND INCIDENCE OF COELIAC DISEASE IN PATIENTS WITH RHEUMATOID ARTHRITIS: A CASE-CONTROL STUDY BASED ON THE RECORD COHORT

Provisionally accepted
Garifallia Sakellariou Garifallia Sakellariou 1,2*ANNALISA SCHIEPATTI ANNALISA SCHIEPATTI 1,3Anna Zanetti Anna Zanetti 4Carlomaurizio Montecucco Carlomaurizio Montecucco 1,5Federico Biagi Federico Biagi 1,3Carlo Alberto Scirè Carlo Alberto Scirè 4,6
  • 1 Dipartimento di Medicina Interna e Terapia Medica, Università di Pavia, PAVIA, Italy
  • 2 Istituti Clinici Scientifici Maugeri IRCCS, Pavia, PAVIA, Italy
  • 3 Istituti Clinici Scientifici Maugeri IRCCS, Gastroenterology Unit, Pavia, Italy, PAVIA, Italy
  • 4 SIR Epidemiology, Research Unit, Milan, Italy, Milano, Italy
  • 5 Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, PAVIA, Italy
  • 6 School of Medicine, University of Milano Bicocca, Milan, Italy, Milano, Italy

The final, formatted version of the article will be published soon.

    Background. The reported prevalence of coeliac disease (CD) in rheumatoid arthritis (RA) is variable.Objective. To evaluate the prevalence and incidence of CD in RA and controls.Design. Case-control study on administrative data.Methods. The RECord linkage On Rheumatic Disease database (administrative data, 2004-2013) was used to retrieve patients with RA and age and sex-matched controls. Prevalence and incidence of CD were calculated and stratified according to age, gender, and calendar year.Results. The cohort included 346,956 subjects (mean age 59.9 (14.5), 70.7% females), of which 70,061 RA and 276,895 controls. Median follow-up was 9 years (IQR 9-9). The prevalence of CD was higher in RA (171/70,061 = 0.24% (0.2-0.3%) vs 398/276895 = 0.14% (0.1-0.2%), p<0.001). The proportion of females withThe prevalence of CD among females with RA was increased compared to controls CD was higher in RA (0.3% vs 0.08%, p<0.001), but was not increased in males with RA. The incidence was higher in RA and remained stable throughout the observation period.Conclusion. The prevalence and incidence of CD were increased in RA, particularly in females.

    Keywords: Rheumatoid arthritis, coeliac disease, Epidemiology, Comorbidity, Disability

    Received: 26 Jul 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Sakellariou, SCHIEPATTI, Zanetti, Montecucco, Biagi and Scirè. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Garifallia Sakellariou, Dipartimento di Medicina Interna e Terapia Medica, Università di Pavia, PAVIA, Italy

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