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ORIGINAL RESEARCH article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1469275
This article is part of the Research Topic Differences Between Emmetropic and Myopic Eyes: Implications for Myopia Development, its Progression, and Ocular Health View all 6 articles

Effects of computer-generated patterns with different temporal and spatial frequencies on choroidal thickness, retinal dopamine and candidate genes in chickens wearing lenses

Provisionally accepted
Hong Liu Hong Liu 1,2Frank Schaeffel Frank Schaeffel 1Marita Pauline Feldkaemper Marita Pauline Feldkaemper 1,3*
  • 1 Section of Neurobiology of the Eye, Ophthalmic Research Intitute, University of Tuebingen, 72076 Tuebingen, Germany
  • 2 Aier Institute of Optometry and Vision Science, Aier Eye Hospital Group, Changsha, 410000 Changsha, China
  • 3 University of Tübingen, Tübingen, Germany

The final, formatted version of the article will be published soon.

    Version July 19October 17, 2024 vitreal level of dopamine metabolites. Retinal EGR-1 mRNA level was positively correlated with choroidal thickness. Retinal OPN4 melanopsin mRNA was increased by 10 Hz-ON stimulation and choroidal BMPR1A mRNA increased with 10 Hz-OFF stimulation. Averaged overOn average all experiments, early choroidal thinning did not predict the amount of negative lens-induced eye growth changes after 7 days, whereas later ChT changes showed a weak association.Negative lenses caused long-lasting choroidal thinning, with some recovery during lens wear, especially after stimulation with 10 Hz.The dynamic stimuli modulated choroidal thinning but effects were small.There was little difference between ON and OFF stimulation, perhaps because the checkerboard patterns were too coarse. 10 Hz cycle frequency increased dopamine release. Less dopamine was correlated with thinner choroids. Result do not exclude a predictive value of choroidal thickeningChT for future refractive development since we almost exclusively tested choroidal thinning effects.

    Keywords: Choroid, Myopia, artificial visual stimuli, Dopamine, EGR-1, chicken

    Received: 23 Jul 2024; Accepted: 23 Oct 2024.

    Copyright: © 2024 Liu, Schaeffel and Feldkaemper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Marita Pauline Feldkaemper, University of Tübingen, Tübingen, Germany

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