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ORIGINAL RESEARCH article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1469200

Association between systemic immune-inflammation index and cataract among outpatient US adults

Provisionally accepted
Jin Huang Jin Huang Hongjiang Wu Hongjiang Wu Fang Yu Fang Yu Fangkun Wu Fangkun Wu Chen Hang Chen Hang Xiaoya Zhang Xiaoya Zhang Yiting Hao Yiting Hao Hao Fu Hao Fu Hongting Xu Hongting Xu Rong Li Rong Li Ding Chen Ding Chen *
  • Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Background: While several studies have noted a higher SII correlates with multiple diseases, research on the association between SII and cataract remains limited. Our cross-sectional study seeks to examine the association between SII and cataract among outpatient US adults.Methods: This compensatory cross-sectional study utilized NHANES data from 1999-2008 cycles, conducting sample-weighted multivariate logistic regression and stratified analysis of subgroups.Results: Among 11,205 adults included in this study (5,571 [46.2%] male; 5,634 [53.8%] female), 2,131 (15.2%) had cataract and 9,074 (84.8%) did not have cataract.A fully adjusted model showed that SII higher than 500 × 10 9 /L was positively correlated with an increased risk of cataracts among women (OR, 1.27; 95% CI, 1.02-1.59) (P= 0.036). However, no difference was found in the men subgroup, and there was no significant interaction between SII and sex.Our results indicated that a SII higher than 500 × 10 9 /L was positively correlated with an increased risk of cataracts in women. This study is the first to specifically investigate the impact of a high SII on cataract risk in outpatient adults in the United States. By effectively addressing inflammation, it is possible to mitigate cataract progression and significantly enhance patient outcomes.

    Keywords: Cataract, Systemic immune-inflammation index (SII), Cross-sectional study, national Health and Nutrition Examination Survey (NHANES), Outpatient US Adults

    Received: 23 Jul 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Huang, Wu, Yu, Wu, Hang, Zhang, Hao, Fu, Xu, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ding Chen, Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.