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ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1466754

A Prediction Model to Differentiate Transient Ischemia from Irreversible Transmural Necrosis in Closed-Loop Small Bowel Obstruction

Provisionally accepted
Shaorong Pan Shaorong Pan 1Jiejin Yang Jiejin Yang 1*Zining Liu Zining Liu 2Rile Nai Rile Nai 1*Zeyang Chen Zeyang Chen 1*
  • 1 First Hospital, Peking University, Beijing, China
  • 2 Center for National Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    The study aims to develop a prediction model to differentiate transient ischemia from irreversible transmural necrosis in closed-loop small bowel obstruction (CL-SBO).Methods: A total of 180 participants with CL-SBO between January 2010 and December 2019, of which 122 had complete radiologic data, were included to investigate the significant clinical and imaging characteristics for differentiating patients with necrosis from transient ischemia. A logistic regression model was developed and validated.In a multivariate analysis, the American Society of Anesthesiologists physical status classification system ＞2 is the independent predictor for transmural necrosis. Another multivariate analysis, including clinical and imaging factors, revealed that the imaging sign of mesenteric vessel interruption was an independent risk factor for necrosis. The diagnostic model developed using these two factors has excellent performance among the validation sets, with an area under the curve of 0.89.The diagnostic model and innovative imaging signs have substantial potential in solving this complex clinical problem.Small bowel obstruction (SBO) is one of the most common acute abdomen diseases, with

    Keywords: closed-loop small bowel obstruction, bowel ischemia, Bowel necrosis, computed tomography, Diagnostic model

    Received: 18 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Pan, Yang, Liu, Nai and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiejin Yang, First Hospital, Peking University, Beijing, China
    Rile Nai, First Hospital, Peking University, Beijing, China
    Zeyang Chen, First Hospital, Peking University, Beijing, China

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