Skip to main content

ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1466574
This article is part of the Research Topic Pathophysiology, Treatment and Rehabilitation of Neurodegenerative Diseases in Geriatric Population View all 8 articles

Objectively measured levels of moderate to vigorous intensity physical activity are associated with cognitive impairment in diabetic hemodialysis patients: a cross-sectional study

Provisionally accepted
Zhixin Zhang Zhixin Zhang 1,2,3Xiaoyu Chen Xiaoyu Chen 2,3Siqin Gaowa Siqin Gaowa 4Ruiting Liang Ruiting Liang 1,2,3Zhetong Jin Zhetong Jin 3Ziyi Shi Ziyi Shi 3Peipei Han Peipei Han 2,3Cheng Lin Cheng Lin 5Xiaoli Wen Xiaoli Wen 4Peng Lin Peng Lin 4Qi Guo Qi Guo 2,3*
  • 1 Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, School of Social Sports and Health Sciences, Tianjin University of Sport, Tianjin, China
  • 2 Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China
  • 3 Shanghai University of Medicine and Health Sciences, Shanghai, China
  • 4 Department of Cardiovascular, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia Autonomous Region, China
  • 5 School of Health, Fujian Medical University, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    The purpose of this study was to observe the relationship between objectively measured levels of physical activity and cognitive impairment (CI) in the presence or absence of diabetes in middle-aged and elderly hemodialysis patients.: In this multicenter cross-sectional study, 339 clinically stable hemodialysis patients (210 males; mean age: 67.38±8.07 years) aged ≥55 years were included from 7 dialysis units in Shanghai, China. The Chinese version of the Modified Mini-Mental State Examination (MMSE) was used to assess the CI. The duration of physical activity at different intensities, including moderate to vigorous physical activity (MVPA) as well as light physical activity (LPA), was measured using a triaxial accelerometer (ActiGraph GT3X+, Pensacola, FL, USA). Logistic regression and multiple linear regression were used for analyses.Results: The prevalence of CI was higher in hemodialysis patients with comorbid diabetes (24.3%).In diabetic patients, MVPA (increase per 10min/day) was negatively associated with CI after adjusting for covariates [(OR=0.89, 95%CI=0.79-0.99), P=0.042]. However, no significant association between physical activity and CI was found in non-diabetic hemodialysis patients.Further analyses revealed that MVPA was positively associated with temporal orientation, attention and calculation and recall in diabetic hemodialysis patients.Physical activity was associated with CI in diabetic hemodialysis patients rather than the non-diabetes group. This study is important for early differential diagnosis of CI and improvement of cognitive status in hemodialysis patients.

    Keywords: physical activity, Hemodialysis (HD), accelerometer, diabetes, Cognitive impairment (CI)

    Received: 18 Jul 2024; Accepted: 08 Oct 2024.

    Copyright: © 2024 Zhang, Chen, Gaowa, Liang, Jin, Shi, Han, Lin, Wen, Lin and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qi Guo, Shanghai University of Medicine and Health Sciences, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.