AUTHOR=Hofmann Heidelore , Margos Gabriele , Todorova Antonia , Ringshausen Ingo , Kuleshov Konstantin , Fingerle Volker 

TITLE=Case report of disseminated borrelial lymphocytoma with isolation of Borrelia burgdorferi sensu stricto in chronic lymphatic leukemia stage Binet A—an 11 year follow up

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1465630

DOI=10.3389/fmed.2024.1465630

ISSN=2296-858X

ABSTRACT=<p>We report a rare manifestation of cutaneous borreliosis in a patient with pre-existing malignant lymphoproliferative disease, in particular chronic lymphocytic B cell leukemia (B-CLL). The patient’s cutaneous lesions were initially diagnosed histologically as leukemia cutis. Distribution pattern of the skin lesions were in typical localizations for borrelial lymphocytoma. <italic>Borrelia burgdorferi</italic> sensu stricto was isolated and cultured from two sites (ear, mammilla). Antibiotic therapy improved the cutaneous lesions and the general condition of the patient. However, a second round of antibiotic therapy was required to resolve the lesions. At eleven years of follow-up the patient’s skin was clear and she still had a stable condition of B-CLL without chemotherapy. In conclusion, the patient suffered from Lyme borreliosis (<italic>Borrelia</italic> lymphocytoma) and the cutaneous symptoms were aggravated by the underlying condition of chronic B-CLL condition.</p>