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ORIGINAL RESEARCH article

Front. Med.
Sec. Hematology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1463086
This article is part of the Research Topic Immune Thrombocytopenia (ITP) - Diagnosis and Treatment - Volume II View all 3 articles

Effect of peripheral blood absolute monocyte count at admission on relapse-free survival in patients with idiopathic thrombotic thrombocytopenic purpura in remission

Provisionally accepted
XiaoMin Yu XiaoMin Yu 1Mingzhu Zhong Mingzhu Zhong 2Chen Wang Chen Wang 1Yifen Shi Yifen Shi 3Chongyun Xing Chongyun Xing 3Yu Kang Yu Kang 3Ying Lin Ying Lin 4Rongying Ou Rongying Ou 2*Junjun Yang Junjun Yang 5*Liqing Zhu Liqing Zhu 1*
  • 1 Department of Clinical Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 2 Department of Obstetrics and Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 3 Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 4 Department of Hematology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
  • 5 Department of Clinical Laboratory, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Peripheral monocytes have been reported to correlate with clinical outcomes in various types of malignancies. Previous reports have also shown that acute-phase thrombotic thrombocytopenic purpura (TTP) plasma could induce the activation of monocytes. However, the significance of peripheral blood absolute monocyte count (AMC) in idiopathic TTP remains an unanswered question. The primary aim of this retrospective study was to evaluate the prognostic value of AMC at admission in idiopathic TTP patients in remission. A total of 37 patients with idiopathic TTP who survived their first episode of the disease and achieved remission following treatment were eligible for inclusion in the study. There were 1 patient (2.7%) with low AMC (< 0.12 × 10 9 /L), 27 patients (73.0%) with normal AMC (0.12-0.80 × 10 9 /L), and 9 patients (24.3%) with high AMC (> 0.80 × 10 9 /L) at admission. Ten (27.0%) of 37 patients in our cohort subsequently relapsed (1 in the low AMC group and 9 in the normal AMC group). Survival analysis showed that there was a trend of higher relapse-free survival (RFS) rate in patients having increased AMC (log-rank test, P = 0.026). Univariate analysis revealed that increased AMC at admission was significantly associated with higher RFS (hazard ratio = 0.12, 95% confidence interval: 0.02-0.62, P = 0.011). Our results suggest that increased AMC at admission could represent a predictor of higher RFS in TTP patients having survived their first episode of the disease and achieved remission following treatment. 11 (2-40) 20 12 (3-40) 8 (2-21) 0.350 £ Comparison between normal and high AMC groups. 457 * value available for 28 patients.

    Keywords: Purpura, thrombotic thrombocytopenic, monocyte, prognostic, relapse-free survival

    Received: 11 Jul 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Yu, Zhong, Wang, Shi, Xing, Kang, Lin, Ou, Yang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rongying Ou, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Junjun Yang, Department of Clinical Laboratory, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
    Liqing Zhu, Department of Clinical Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.