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ORIGINAL RESEARCH article

Front. Med.
Sec. Nuclear Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1462870

99m Tc-FAPI-04 SPECT/CT Outperforms Contrast-Enhanced CT in Detecting Metastasis in Postoperative Patients with Colorectal Cancer

Provisionally accepted
Donghua Sun Donghua Sun 1Li Ma Li Ma 2Yan Liu Yan Liu 1Caili Bao Caili Bao 1Guorong Jia Guorong Jia 2Tao Wang Tao Wang 2*Yingqiu Wang Yingqiu Wang 1*
  • 1 Yangpu Hospital, Tongji University, Yangpu, Shanghai, China
  • 2 The First Affiliated Hospital of Naval Medical University, Shanghai, China

The final, formatted version of the article will be published soon.

    Purpose: To compare the performance of 99m Tc-FAPI-04 SPECT/CT and contrast-enhanced CT (CECT) in the detection of postoperative metastasis in patients with colorectal cancer (CRC).The postoperative patients with CRC were consecutively recruited from January 2023 to June 2023, and the enrolled patients completed 99m Tc-FAPI-04 SPECT/CT imaging and CECT examination within two weeks. Histopathological analysis and the follow-up results were used as the reference criteria. The location and number of metastatic sites and the detection accuracy between the two imaging methods were compared. The tumor-to-background ratio (TBR) of liver metastasis and lymph node metastasis in 99m Tc-FAPI-04 SPECT/CT imaging were also calculated for comparison.In total, 19 postoperative CRC patients, including 15 patients with metastasis, were included in this study. In the patient-based analysis, 99m Tc-FAPI-04 SPECT/CT showed a significantly higher sensitivity for the detection of metastasis than CECT (93.3% vs. 80.0%, P = 0.038), but both techniques had the same specificity (100%, 4/4). For the lesion-based analysis, the detection rates of metastatic sites were 92.2% (47/51) and 72.5% (37/51) for 99m Tc-FAPI-04 SPECT/CT and CECT, respectively, and the difference between them was statistically significant. In the diagnosis of liver metastasis and lymph node metastasis, 99m Tc-FAPI-04 SPECT/CT both exceeded CECT. Additionally, the TBR in lymph node metastasis was higher than that in liver metastasis.The findings suggested that 99m Tc-FAPI-04 SPECT/CT could detect metastasis more effectively than CECT, especially liver and lymph node metastases, in postoperative CRC patients.

    Keywords: 99m Tc-FAPI-04, SPECT/CT, Contrast-enhanced CT, colorectal cancer, metastasis

    Received: 10 Jul 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Sun, Ma, Liu, Bao, Jia, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tao Wang, The First Affiliated Hospital of Naval Medical University, Shanghai, China
    Yingqiu Wang, Yangpu Hospital, Tongji University, Yangpu, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.