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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1462637
This article is part of the Research Topic Body Composition Assessment and Future Disease Risk View all 5 articles

Correlation between body mass index and gender-specific 28-day mortality in patients with sepsis: a retrospective cohort study

Provisionally accepted
Li Zhang Li Zhang *Chong Li Chong Li Huaping Huang Huaping Huang Qingjie Xia Qingjie Xia
  • First People's Hospital of Kunshan, Kunshan, China

The final, formatted version of the article will be published soon.

    Objective: To investigate the potential correlation between body mass index (BMI) and the 28-day mortality rate among sepsis patients and the gender difference in this association.The current research was a retrospective cohort study.Participants: A total of 14,883 male and female cohorts of sepsis patients were included in the Medical Information Mart for Intensive Care IV (MIMIC-IV V2.2) database. Patients in each gender cohort were further classified as underweight, normal weight, overweight, or obese according to their WHO BMI and the World Health Organization (WHO) BMI categories.Outcomes: The 28-day mortality from the date of ICU hospitalization was the primary outcome measure.The BMI and 28-day mortality exhibited an L-shaped relationship (p for nonlinearity < 0.001) with significant genderspecific differences. Subgroup analysis revealed different association patterns between the male and female cohorts.Specifically, BMI and mortality exhibited a U-shaped curve relationship among the males (p for nonlinearity < 0.001) and an L-shaped relationship among the females (p for nonlinearity = 0.04538).This study proposes a link between extreme BMI and 28-day mortality in patients with sepsis. Underweight patients have an increased risk of mortality; however, this risk decreases in overweight and obese patients. Upon stratifying by sex, a U-shaped pattern was observed, indicating an association between BMI and 28-day mortality in males, while an L-shaped pattern emerged in females.

    Keywords: Obesity, Mortality, Body Mass Index, gender, Sepsis

    Received: 10 Jul 2024; Accepted: 17 Sep 2024.

    Copyright: © 2024 Zhang, Li, Huang and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Zhang, First People's Hospital of Kunshan, Kunshan, China

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