Skip to main content

SYSTEMATIC REVIEW article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1462513

Evaluating the Roles of MicroRNAs Associated with Nonalcoholic Fatty Liver Disease in Hepatocellular Carcinoma Tumorigenesis: A Systematic Review and Network Analysis

Provisionally accepted
Qinghua Peng Qinghua Peng 1Xiaoning Zhu Xiaoning Zhu 1,2Yuanyuan Jiang Yuanyuan Jiang 1*Mengyun Peng Mengyun Peng 1*Ding Zheng Ding Zheng 1*Xiaodong Wang Xiaodong Wang 1*Yoke Kqueen Cheah Yoke Kqueen Cheah 2Jing Wang Jing Wang 1*
  • 1 Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China
  • 2 Department of Biomedical Sciences, Faculty of Medicine and Health sciences, University of Putra Malaysia, Serdang, Selangor, Malaysia

The final, formatted version of the article will be published soon.

    Nonalcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease worldwide. Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide, with high morbidity and mortality. The rapidly increasing incidence of NAFLD is becoming an essential precursor of HCC globally. MicroRNAs (miRNAs) are involved in the progression of NAFLD and HCC. This study aims to evaluate the roles of miRNAs associated with NAFLD in HCC tumorigenesis through systematic review and data mining analysis. The roles of the potential miRNA and its target genes in NAFLD and HCC were evaluated by bioinformatic analysis. First, MIR122 was identified as the potential miRNA associated with NAFLD and HCC.Then, MIR122 expression was significantly lower in HCC patients, and higher MIR122 levels were associated with significantly better overall survival. Next, the biological functions of MIR122 and target genes were predicted to be involved in inflammation, fibrosis, cell proliferation, invasion, metastasis, and apoptosis. In particular, the FOXO signaling pathway may regulate the above biological functions. In the end, MIR122 was suggested to be involved in progressing from NAFLD to HCC through the PI3K/AKT/FOXO pathway.

    Keywords: nonalcoholic fatty liver disease, Hepatocellular Carcinoma, MicroRNAs, biological functions, signaling pathway, Systematic review

    Received: 11 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Peng, Zhu, Jiang, Peng, Zheng, Wang, Cheah and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuanyuan Jiang, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China
    Mengyun Peng, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China
    Ding Zheng, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China
    Xiaodong Wang, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China
    Jing Wang, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.