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ORIGINAL RESEARCH article

Front. Med.
Sec. Obstetrics and Gynecology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1462079

Analysis of Factors Affecting the Accuracy of Colposcopic Diagnosis of Cervical Lesions: A Retrospective Cohort Study

Provisionally accepted
Yuqing Chu Yuqing Chu Qi Chen Qi Chen Ruixue Liu Ruixue Liu Xu Zhou Xu Zhou Meijing Bao Meijing Bao Hong Wang Hong Wang Yang Lin Yang Lin *
  • Department of Obstetrics and Gynecology, Second Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Background: Cervical cancer is a leading cause of cancer-related deaths among women. However, in developing countries, the primary focus for cervical cancer prevention and control remains on the timely detection and treatment of precancerous lesions. This study aims to evaluate the accuracy of colposcopic diagnosis of cervical intraepithelial lesions and analyze the factors influencing its accuracy.Methods: This study collected data from 512 eligible patients who visited the gynecology outpatient clinic of the Second Hospital of Jilin University from January 2022 to August 2023. The final diagnosis was based on the highest grade observed in both biopsy pathology and postoperative pathology. A selfcontrolled, retrospective analysis was conducted to evaluate the accuracy of colposcopic diagnosis. Univariate analysis was used to assess the impact of factors such as menopausal status, duration of menopause, high-risk human papillomavirus (HR-HPV) genotypes, and transformation zone (TZ) types on the accuracy of colposcopic diagnosis of cervical lesions.The overall colposcopy diagnostic concordance rate was 78.71%. The concordance rates between the premenopausal and postmenopausal groups differed significantly (X² =75.450, P<0.05). The HPV16/18 positive group and the Non-16/18 HR-HPV positive group also showed a significant difference in concordance rates (X² =5.890, P<0.05). There were significant differences in concordance rates between TZ2 and TZ3 (X² =10.585, P<0.05), as well as between TZ1 and TZ3 (X² =14.607, P<0.05).Conclusions: Factors such as menopausal status, duration of menopause, HR-HPV genotypes, and TZ types influence the accuracy of colposcopic diagnosis. Therefore, a comprehensive evaluation incorporating these factors should be performed in clinical practice to enhance diagnostic accuracy.

    Keywords: colposcopy1, cervical cancer screening2, HPV3, cervical precancer4, diagnostic accuracy5

    Received: 09 Jul 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Chu, Chen, Liu, Zhou, Bao, Wang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yang Lin, Department of Obstetrics and Gynecology, Second Hospital of Jilin University, Changchun, Jilin Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.