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REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1460233

Comparative Analysis of SDC2 and SEPT9 Methylation Tests in the Early Detection of Colorectal Cancer: A Systematic Review and Meta-Analysis

Provisionally accepted
Jie Zhang Jie Zhang Chenhui Li Chenhui Li Yu An Yu An Bing Wang Bing Wang Guowei Liang Guowei Liang *
  • Aerospace Center Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    Purpose: This meta-analysis aimed to evaluate the comparative diagnostic efficacy of Syndecan-2(SDC2) and Septin-9(SEPT9) in the early detection of colorectal cancer(CRC). Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library databases to identify available publications up to October 2024. A direct head-to-head comparator analysis were performed using the random-effects model. Subgroup analyses and corresponding meta-regressions focusing on sample source, number of patients, region, study design, and methylated detection methods were conducted. Intra-group and inter-group heterogeneity were assessed by Cochrane Q and I2 statistics. Results: 11 articles involving 1,913CRC patients and 2,851 healthy people were included in the meta-analysis. The sensitivity of SDC2 was similar compared to SEPT9 for CRC patients (0.67 vs. 0.71, P=0.61), SDC2 has a similar specificity in comparison to SEPT9 for CRC patients (0.90 vs. 0.91, P = 0.86). In subgroup analysis, stool SDC2 was similar compared to stool SEPT9 for CRC patients (sensitivity of 0.81 vs. 0.80, P=0.92; specificity of 0.93 vs 0.91, P=0.73), plasma SDC2 was similar compared to plasma SEPT9 for CRC patients (sensitivity of 0.57 vs. 0.72, P=0.27; specificity of 0.90 vs 0.89, P=0.89). In the subgroup analysis of clinical staging for colorectal cancer (CRC), the results indicate that there is no significant difference in sensitivity between the two markers for both early (0.7 vs 0.67, P=0.64) and advanced (0.76 vs 0.70, P=0.23) stages of CRC. Conclusions: In our head-to-head comparison meta-analysis, it was found that SDC2 and SEPT9 have similar sensitivity and specificity in the diagnosis of colorectal cancer. However, this result may be influenced by high heterogeneity and further confirmation of this finding is needed through large-scale prospective studies.

    Keywords: SDC2, SEPT9, detection, colorectal cancer, Meta-analysis

    Received: 05 Jul 2024; Accepted: 18 Oct 2024.

    Copyright: © 2024 Zhang, Li, An, Wang and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guowei Liang, Aerospace Center Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.