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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1458417

Impact of Beta-Blocker Usage on Delirium in Patients with Sepsis in ICU: A Cross-sectional Study

Provisionally accepted
Yi Yu Yi Yu 1*Honglian Ouyang Honglian Ouyang 1Xiaoqi Wang Xiaoqi Wang 2Dingwei Deng Dingwei Deng 1Qianqian Wang Qianqian Wang 3
  • 1 Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China
  • 2 Sichuan Provincial Hospital for Women and Children, Chengdu, Sichuan Province, China
  • 3 The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Delirium in patients with sepsis can be life-threatening. This study aims to investigate the impact of the use of beta-blockers on the occurrence of delirium in patients with sepsis in the ICU by utilizing a comprehensive dataset. This is a cross-sectional study conducted using the data obtained from a single ICU in the USA. Patients diagnosed with sepsis and receiving beta-blockers were compared with those not receiving beta-blockers. Propensity score matching (PSM) and multiple regression analysis were employed to adjust for potential confounders. Among the 19,660 patients hospitalized for sepsis, the beta-blocker and non-user groups comprised 13,119 (66.73%) and 6,541 (33.27%) patients, respectively. Multivariable logistic regression models revealed a significant reduction of 60% in 7-day delirium for beta-blocker users (OR = 0.40, 95% CI: 0.37-0.43, P < 0.001), for 30-day delirium (OR = 0.32, 95% CI: 0.29-0.35, P < 0.001), and for 90-day delirium (OR = 0.33, 95% CI: 0.30-0.35, P < 0.001). The PSM results further strengthen the validity of these findings. An analysis of safety issues demonstrated that beta-blockers may have an impact on the risk of acute kidney injury. However, following PSM, the results are not considered robust. Furthermore, there was no discernible change in the odds of renal replacement therapy and the length of ICU stays. Our findings suggest a potential protective effect of beta-blockers against delirium in patients with sepsis.Nevertheless, the observational design limits causal inference, necessitating future randomized controlled trials to validate these findings.

    Keywords: beta-blockers, Delirium, Sepsis, Acute Kidney Injury, ICU stay, mimic iv

    Received: 02 Jul 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Yu, Ouyang, Wang, Deng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yi Yu, Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.