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REVIEW article

Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1457882

Focus on the role of calcium signaling in ferroptosis: a potential therapeutic strategy for sepsis-induced acute lung injury

Provisionally accepted
Yifei Xu Yifei Xu 1*Xintian Qu Xintian Qu 1Minghao Liang Minghao Liang 1Di Huang Di Huang 1Minyan Jin Minyan Jin 1*Lili Sun Lili Sun 1*Xianhai Chen Xianhai Chen 2*Fen Liu Fen Liu 3*Zhanjun Qiu Zhanjun Qiu 2*
  • 1 Shandong University of Traditional Chinese Medicine, Jinan, China
  • 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
  • 3 The First Affiliated Hospital of Shandong First Medical University, jinan, China

The final, formatted version of the article will be published soon.

    By engaging in redox processes, ferroptosis plays a crucial role in sepsis-induced acute lung injury (ALI). Although iron stimulates calcium signaling through the stimulation of redox-sensitive calcium pathways, the function of calcium signals in the physiological process of ferroptosis in septic ALI remains unidentified. Iron homeostasis disequilibrium in ferroptosis is frequently accompanied by aberrant calcium signaling. Intracellular calcium overflow can be a symptom of dysregulation of the cellular redox state, which is characterized by iron overload during the early phase of ferroptosis. This can lead to disruptions in calcium homeostasis and calcium signaling. The mechanisms controlling iron homeostasis and ferroptosis are reviewed here, along with their significance in sepsis-induced acute lung injury, and the potential role of calcium signaling in these processes is clarified. We propose that the development of septic acute lung injury is a combined process involving the bidirectional interaction between iron homeostasis and calcium signaling. Our goal is to raise awareness about the pathophysiology of sepsis-induced acute lung injury and investigate the relationship between these mechanisms and ferroptosis. We also aimed to develop calcium-antagonistic therapies that target ferroptosis in septic ALI and improve the quality of survival for patients suffering from acute lung injury.

    Keywords: Calcium Signaling, Sepsis-Induced Acute Lung Injury, ferroptosis, iron homeostasis, calcium homeostasis

    Received: 01 Jul 2024; Accepted: 05 Sep 2024.

    Copyright: © 2024 Xu, Qu, Liang, Huang, Jin, Sun, Chen, Liu and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yifei Xu, Shandong University of Traditional Chinese Medicine, Jinan, China
    Minyan Jin, Shandong University of Traditional Chinese Medicine, Jinan, China
    Lili Sun, Shandong University of Traditional Chinese Medicine, Jinan, China
    Xianhai Chen, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
    Fen Liu, The First Affiliated Hospital of Shandong First Medical University, jinan, China
    Zhanjun Qiu, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.