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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1453694
This article is part of the Research Topic Regional Anesthesia, Pain Medicine, and Regenerative Medicine for Enhanced Patient Care View all articles

Prospective case-control study on pain intensity after the use of promethazine in patients undergoing videothoracoscopy

Provisionally accepted
Xiangwei Zhou Xiangwei Zhou 1*Benhui He Benhui He 1*Xia Zheng Xia Zheng 1*Chao Li Chao Li 2*Zeyu Mi Zeyu Mi 2*Mingqing Peng Mingqing Peng 1*Min Li Min Li 1*
  • 1 Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
  • 2 Department of thoracic and cardiovascular Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Objective: Effective and secure pain management following video-assisted thoracoscopic surgery (VATS) is crucial for rapid postoperative recovery. This study evaluated analgesic and sedative effects of sufentanil and promethazine in patient-controlled intravenous analgesia (PCIA) postthoracic surgery, along with potential adverse reactions.In this prospective, randomized, controlled, double-blind, clinical study, 60 patients (American Society of Anesthesiologists status I-III) undergoing VATS were enrolled. The patients were randomized into experimental (Group P) or control (Group C) groups. PCIA was administered post-general anesthesia using a double-blind method. Group P received sufentanil (3 g/kg) + promethazine (1 mg/kg) + 0.9% sodium chloride solution (100 mL total), while Group C received sufentanil (3 g/kg) + 0.9% sodium chloride solution (100 mL total). PCIA settings included a 1-mL bolus and 15-min locking time. The primary outcomes were the visual analog scale (VAS) at rest and during coughing and sedation (Ramsay) scores at 6, 12, 24, and 48 h. The secondary outcomes were rescue drug use rate, hemodynamic parameters (mean arterial pressure and heart rate), percutaneous oxygen saturation, respiratory rate, and occurrence of adverse reactions.Results: Group P exhibited lower resting and coughing VAS scores at 6, 12, 24, and 48 h, plus decreased incidence of nausea and vomiting within 48 h post-surgery compared with Group C (P<0.05). No significant differences were observed in pruritus, sedation (Ramsay) scores, mean arterial pressure, heart rate, oxygen saturation, or respiratory rate between the two groups (P>0.05).The combination of sufentanil and promethazine for postoperative intravenous analgesia could effectively reduce adverse effects such as nausea and vomiting, contributing to postoperative pain relief.

    Keywords: Promethazine, Sufentanil, Video-assisted thoracoscopic surgery (VATS), patientcontrolled intravenous analgesia, Thoracic Surgery

    Received: 23 Jun 2024; Accepted: 29 Aug 2024.

    Copyright: © 2024 Zhou, He, Zheng, Li, Mi, Peng and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiangwei Zhou, Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Benhui He, Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Xia Zheng, Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Chao Li, Department of thoracic and cardiovascular Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Zeyu Mi, Department of thoracic and cardiovascular Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Mingqing Peng, Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China
    Min Li, Department of Anesthesiology and Perioperative Medicine, Yongchuan Hospital of Chongqing Medical University, Chongqing, China

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