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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1452811
This article is part of the Research Topic Frailty- and Age-Associated Diseases: Possibilities For Intervention (Volume 2) View all articles

Hand Grip Strength and All-Cause Mortality Risk in Individuals with Decreased Abnormal Bone Mass: A Study from NHANES Database

Provisionally accepted
Hongdong Sun Hongdong Sun 1Jiayi Liu Jiayi Liu 1*Ruirui Tan Ruirui Tan 1*Xiaomei Zhang Xiaomei Zhang 1*Xin Qian Xin Qian 2*Chenxi Qi Chenxi Qi 3*Wei Qi Wei Qi 4*
  • 1 Changchun University of Chinese Medicine, Changchun, China
  • 2 Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China
  • 3 Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
  • 4 Bao'an Authentic TCM Therapy Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Abstract Objective: Previous studies have demonstrated that grip strength is associated with various health outcomes, including osteoporosis. However, the impact of grip strength on long-term mortality risk among individuals with low bone mass remains unclear. This study aims to investigate the association between grip strength and the risk of all-cause mortality in the population with low bone mass. Methods: We included 1343 cases of decreased bone mass from the NHANES database spanning 2013 to 2014. All-cause mortality data were ascertained through linkage with national death index records up to December 31, 2015. Analysis was conducted using the Cox proportional hazards regression model, and we assessed result reliability through various model adjustments and hierarchical analyses,Schoenfeld’s global and individual tests are utilized to estimate the time-varying covariance in the Cox proportional hazards regression model’s hypothesis. Results: Throughout an average follow-up period of 69.5 months, 148 deaths were documented. After adjusting for covariates, a significant association between grip strength and the risk of all-cause mortality was observed in individuals with decreased bone mass (HR=0.9, 95% CI: 0.87-0.93, p<0.001). Individuals with normal grip strength, compared to those with low grip strength, exhibited a 56% lower risk of all-cause mortality (HR=0.44, 95% CI: 0.29-0.67, p<0.05). Various models consistently demonstrated similar significant trends post-adjustment. Subgroup analysis revealed an interaction between grip strength and coronary heart disease (p<0.05). Schoenfeld’s global and individual tests confirmed the reliability of the model (p>0.05). Conclusion: Our findings indicate that low grip strength is associated with increased all-cause mortality risk in individuals with decreased bone mass. The inclusion of routine monitoring of grip strength in patients with osteopenia and the encouragement of maintaining or improving grip strength in this population may offer a novel approach to health management for these individuals.

    Keywords: Osteoporosis, mortality risk, Grip strength, Aging, NHANES

    Received: 21 Jun 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Sun, Liu, Tan, Zhang, Qian, Qi and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiayi Liu, Changchun University of Chinese Medicine, Changchun, China
    Ruirui Tan, Changchun University of Chinese Medicine, Changchun, China
    Xiaomei Zhang, Changchun University of Chinese Medicine, Changchun, China
    Xin Qian, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen ，Guangdong, China
    Chenxi Qi, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
    Wei Qi, Bao'an Authentic TCM Therapy Hospital, Shenzhen, China

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