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REVIEW article

Front. Med.
Sec. Precision Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1452298
This article is part of the Research Topic Targeted Drug Delivery of Nanocarriers for Tumor Theranostics View all articles

HYBRID-INTEGRATED DEVICES FOR MIMICKING MALIGNANT BRAIN TUMORS ("TUMOR-ON-A-CHIP") FOR IN VITRO DEVELOPMENT OF TARGETED DRUG DELIVERY AND PERSONALIZED THERAPY APPROACHES

Provisionally accepted
Nikita O. Sitkov Nikita O. Sitkov 1,2*Tatiana M. Zimina Tatiana M. Zimina 1,2Kamil G. Gareev Kamil G. Gareev 1,2Natalia V. Mikhailova Natalia V. Mikhailova 2,3Stephanie E. Combs Stephanie E. Combs 4Maxim A. Shevtsov Maxim A. Shevtsov 2,4,5
  • 1 Saint Petersburg State Electrotechnical University, Saint Petersburg, Russia
  • 2 Almazov National Medical Research Centre, Saint Petersburg, Russia
  • 3 Other, Saint Petersburg, Russia
  • 4 University Hospital rechts der Isar, Technical University of Munich, Munich, Bavaria, Germany
  • 5 Institute of Cytology and Genetics, Russian Academy of Sciences (RAS), Novosibirsk, Russia

The final, formatted version of the article will be published soon.

    Acute and requiring attention problem of oncotheranostics is a necessity for the urgent development of operative and precise diagnostics methods, followed by efficient therapy, to significantly reduce disability and mortality of citizens. A perspective way to achieve efficient personalized treatment is to use methods for operative evaluation of the individual drug load, properties of specific tumors and the effectiveness of selected therapy, and other actual features of pathology. Among the vast diversity of tumor types -brain tumors are the most invasive and malignant in humans with poor survival after diagnosis. Among brain tumors glioblastoma shows exceptionally high mortality. More studies are urgently needed to understand the risk factors and improve therapy approaches. One of the actively developing approaches is the tumor-on-a-chip (ToC) concept. This review examines the achievements of recent years in the field of ToC system developments. The basics of microfluidic chips technologies are considered in the context of their applications in solving oncological problems. Then the basic principles of tumors cultivation are considered to evaluate the main challengers in implementation of microfluidic devices, for growing cell cultures and possibilities of their treatment and observation. The main achievements in the culture types diversity approaches and their advantages are being analyzed. The modelling of angiogenesis and blood-brain barrier (BBB) on a chip, being a principally important elements of the life system, were considered in detail. The most interesting examples and achievements in the field of tumor-on-a-chip developments have been presented.Brain tumor; tumor-on-a-chip, blood-brain barrier, organ-on-a-chip, microfluidic devices

    Keywords: brain tumor, Tumor-on-a-chip, Blood-Brain Barrier, organ-on-a-chip, microfluidic devices

    Received: 20 Jun 2024; Accepted: 14 Oct 2024.

    Copyright: © 2024 Sitkov, Zimina, Gareev, Mikhailova, Combs and Shevtsov. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nikita O. Sitkov, Saint Petersburg State Electrotechnical University, Saint Petersburg, Russia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.