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SYSTEMATIC REVIEW article

Front. Med.
Sec. Nuclear Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1451565
This article is part of the Research Topic Advances in Imaging of Microenvironment in Oncological and Non-oncological Disease by Nuclear Medicine View all articles

Prostate-Specific Membrane Antigen PET versus [ 99m Tc]Tc-MDP Bone Scan for Diagnosing Bone Metastasis in Prostate Cancer: A Head-to-Head Comparative Meta-Analysis

Provisionally accepted
奕茗 王 奕茗 王 Yiran Qiu Yiran Qiu Xingjian Yan Xingjian Yan *
  • First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China

The final, formatted version of the article will be published soon.

    Purpose: To evaluate the diagnostic performance of PSMA PET/CT, including [ 68 Ga]Ga-PSMA-11 and [ 18 F]DCFPyL, in comparison with the [ 99m Tc]Tc-MDP bone scan(BS) in identifying bone metastases among prostate cancer patients. Methods: A search was performed in the PubMed and Embase databases to locate pertinent publications from inception to February 12, 2024. The studies included were those that examined the diagnostic effectiveness of PSMA PET/CT (covering [ 68 Ga]Ga-PSMA-11 and [ 18 F]DCFPyL) compared to [ 99m Tc]Tc-MDP BS in identifying bone metastases among prostate cancer patients.The quality of the selected studies was evaluated using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) checklist.The meta-analysis included nine articles involving 702 patients. The sensitivity of PSMA PET/CT was higher compared to [ 99m Tc]Tc-MDP BS (0.98 vs. 0.85, P<0.01), while the specificity of PSMA PET/CT was also higher than [ 99m Tc]Tc-MDP BS (0.97 vs. 0.70,P<0.01).In subgroup analysis, the sensitivity of [ 68 Ga]Ga-PSMA-11 PET/CT was higher compared to [ 99m Tc]Tc-MDP BS (0.98 vs. 0.86), while the specificity of [ 68 Ga]Ga-PSMA-11 PET/CT was also higher than [ 99m Tc]Tc-MDP BS (0.98 vs. 0.65).Our meta-analysis demonstrates that PSMA PET/CT exhibits superior sensitivity and specificity in comparison with [ 99m Tc]Tc-MDP BS for identifying bone metastases in prostate cancer patients. Further research with head-to-head design is necessary to validate these results and evaluate the clinical effectiveness of these imaging methods.

    Keywords: [ 68 Ga]Ga-PSMA-11, [ 18 F]DCFPyL, [ 99m Tc]Tc-MDP Bone Scan, prostate cancer, Bone Metastases

    Received: 19 Jun 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 王, Qiu and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xingjian Yan, First Affiliated Hospital of Jilin University, Changchun, 130012, Jilin Province, China

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