Yixu Li ¹ Yifan Liu ^2,3 Sujie Xie ¹ Yushu Zhu ¹ Xinran Ding ¹ Wei Zhang ¹ Shuyuan Xian ¹ Guosheng Wu ¹ Hanlin Sun ¹ Jiale Yan ⁴ Bingnan Lu ³ Yuntao Yao ³ Weijin Qian ³ Yuwei Lu ³ Yiting Yang ³ Dayuan Xu ¹ Runzhi Huang ¹ Shizhao Ji ^1*

• ¹ Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai, People’s Republic of China, Shanghai, Chad
• ² Department of Urology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China
• ³ Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China, Shanghai, China
• ⁴ Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 2699 Gaoke West Road, Shanghai, 201204, China, Shanghai, China

Objective: Burns lead to systemic changes manifested by systemic disturbances in water-electrolyte balance and systemic metabolic and inflammatory responses. The hypermetabolic response after a burn injury relies on metabolic, hormonal, and inflammatory dysregulation mechanisms. This study aimed to provide a comprehensive bibliometric analysis of the burn metabolism research field, identifying key trends, influential contributors, and emerging research hotspots to inform future investigative efforts.Ultimately, we conducted an extensive review of the literature, synthesizing the findings to clarify the present understanding within our field of study.We obtained 8823 scientific publications on burn injury and metabolism from the core Web of Science (WOS) database collection. In this work, biblioshiny was used to visualize and analyze the data, and VOSviewer was used to verify the results.Results: From a total of 8,823 publications, we found a general upward trend in annual publications and citation frequency. According to Bradford's Law, 21 high-production journals were classified as core sources based on the number of publications, and the most productive journal was Burns. The most published countries and authors in this field were the United States and Herndon DN. The most local cited document in this field was the article titled "Catecholamines: Mediator of the Hypermetabolic Response to Thermal Injury" authored by Wilmore DW. The thematic map showed that studies on injury, thermal injury, and sepsis were relatively mature. In contrast, research on metabolism, stress, and responses, and research on mortality, resistance, and management were less well-developed but were essential for the field.Research on burns and metabolism is increasing. Based on the bibliometric analysis, our study summarized the complex interplay between burn-induced systemic metabolic alterations and inflammatory responses, emphasizing the significance of hypermetabolism and its management. The role of propranolol, insulin, oxandrolone, and nutritional interventions in modulating the hypermetabolic state was discussed. Additionally, our study underscored the challenges of managing sepsis and drug-resistant infections in burn patients as an important future area of research.