The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1450298
This article is part of the Research Topic Translational Approaches in Deciphering the Gut Microbiome's Role in Non-Communicable Diseases View all 5 articles
Exploring the Relationship between Gut Microbiota and Breast Diseases using the Mendelian Randomization Analysis
Provisionally accepted- West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
Background Growing evidence suggests a connection between gut microbiota composition and breast diseases, though the precise nature of this association remains uncertain. To investigate a causal relationship between gut microbiota and breast diseases, we utilized a two-way Mendelian randomization (MR) analysis. Methods Four common diseases, including breast cancer, breast cysts, inflammatory disorders of the breast, and infections of the breast associated with childbirth, as well as their subtypes were brought into as the outcomes. Genetic data of the gut microbiota were extracted from genome-wide association studies (GWAS). The primary approach for investigating the association between these genetic factors and gut microbiota was the inverse-variance-weighted (IVW) method with random-effects types. Sensitivity analyses, such as the Cochran Q test, Egger intercept test, and leave-one-out analysis, were conducted to ensure the stability and reliability of the MR findings. Results We discovered plausible causal links between 20 microbial categories and breast diseases with a significance level of p<0.05. Notably, The Family.Rikenellaceae (p value: 0.0013) maintained a significant inverse relationship with overall breast cancer after Bonferroni correction. In the reverse MR analysis, interactions were observed between Genus.Adlercreutzia and ER+ breast cancer. Additionally, the genus Sellimonas, Family.Rikenellaceae and Genus. Paraprevotella were associated with ER+ and overall breast cancer, whereas the genera Dorea was linked to both ER-and overall breast cancer. Family.Prevotellaceae was the sole category correlated with inflammatory breast disorders. Moreover, Genus Eubacteriumruminantiumgroup, Genus Lactococcus and Family Alcaligenaceae were associated with breast cysts, while Genus Anaerofilum, Genus Butyricimonas, Order Coriobacteriales, Order Pasteurellales and Order Verrucomicrobiales showed significant associations with the infections of breast associated with childbirth. No evidence of heterogeneity or horizontal pleiotropy was found. Conclusion Our mendelian randomization analysis affirmed a causal connection between the gut microbiota and breast diseases. Early stool tests may be a viable practice for disease screening to identify people at higher risk of breast diseases.
Keywords: Gut Microbiota, breast cancer, Breast Diseases, Mendelian randomization, Single Nucleotide Polymorphisms (SNP)
Received: 17 Jun 2024; Accepted: 28 Oct 2024.
Copyright: © 2024 Wang, Gao, Zeng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jie Chen, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.