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ORIGINAL RESEARCH article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1449919

Effects of hemodialysis adequacy on chronic kidney disease complications using latent class trajectory modeling: a real-world study based on long-term observation of Kt/V

Provisionally accepted
SanXi Ai SanXi Ai Qiuyu Xu Qiuyu Xu Gang Chen Gang Chen *Ke Zheng Ke Zheng Yan Qin Yan Qin XueMei Li XueMei Li *
  • Peking Union Medical College Hospital (CAMS), Beijing, China

The final, formatted version of the article will be published soon.

    Introduction: Previous studies on hemodialysis adequacy primarily focused on the association between Kt/V and survival, and low Kt/V is associated with increased mortality. There is a paucity of research on the correlation between Kt/V and chronic kidney disease (CKD) complications.: The retrospective study was conducted in the blood purification center of a tertiary hospital in China from July 2020 to September 2022. It aimed to analyze the association between latent Kt/V trajectory categories and CKD complications (hypertension, anemia, mineral, and bone disorder) and inflammatory markers. The latent class trajectory model was established to describe the different patterns of Kt/V patient changes over the observation period.Results: During the 2-year study period, 93 patients on thrice-weekly hemodialysis with residual kidney function < 2 ml/min were included. In the 3-class Kt/V trajectory model, 21 patients were in class 1 with a Kt/V trajectory that declined from a higher to lower levels (from > 1.6 to < 1.4), 59 patients were in class 2 with Kt/V consistently in a relatively low range (around 1.4), and 13 patients were in class 3 with Kt/V stabilized around 1.6. No significant difference in CKD complications or inflammation markers was observed among the three Kt/V trajectories.Under the premise of adequate Kt/V, neither a stable higher Kt/V nor a declined Kt/V significantly influenced CKD complications or inflammatory markers.

    Keywords: dialysis adequacy, CKD complications, Inflammation, Latent class trajectory model, Kt/v

    Received: 16 Jun 2024; Accepted: 04 Sep 2024.

    Copyright: © 2024 Ai, Xu, Chen, Zheng, Qin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Gang Chen, Peking Union Medical College Hospital (CAMS), Beijing, China
    XueMei Li, Peking Union Medical College Hospital (CAMS), Beijing, China

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