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REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1449037
This article is part of the Research Topic Crosstalk in Ferroptosis, Immunity & Inflammation View all 9 articles

The Important Role of Ferroptosis in Inflammatory Bowel Disease

Provisionally accepted
Xie Hanhan Xie Hanhan 1Cao Chun Cao Chun 2Shu Dan Shu Dan 2Tong Liu Tong Liu 3*Zhang Tao Zhang Tao 2,4*
  • 1 China Nation Nuclear Corporation 416 Hospital, Chengdu, China
  • 2 School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China
  • 3 The Third Affiliated Hospital of Chengdu Medical College , Chengdu Pidu District People’s Hospital, Chengdu, China
  • 4 Chengdu Medical College, Chengdu, China

The final, formatted version of the article will be published soon.

    Ferroptosis is a type of regulated cell death that occurs due to the iron-dependent accumulation of lethal reactive oxygen species (ROS) from lipids. Ferroptosis is characterized by distinct morphological, biochemical, and genetic features that differentiate it from other regulated cell death (RCD) types, which include apoptosis, various necrosis types, and autophagy. Recent reports show that ferritin formation is correlated to many disorders, such as acute injury, infarction, inflammation, and cancer. Iron uptake disorders have also been associated with intestinal epithelial dysfunction, particularly inflammatory bowel disease (IBD). Studies of iron uptake disorders may provide new insights into the pathogenesis of IBD, thereby improving the efficacy of medical interventions. This review presents an overview of ferroptosis, elucidating its fundamental mechanisms and highlighting its significant involvement in IBD.

    Keywords: inflammatory bowel disease, intestinal epithelial cells, ferroptosis, ROS, Mechanism

    Received: 24 Jun 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Hanhan, Chun, Dan, Liu and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tong Liu, The Third Affiliated Hospital of Chengdu Medical College , Chengdu Pidu District People’s Hospital, Chengdu, China
    Zhang Tao, Chengdu Medical College, Chengdu, China

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