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MINI REVIEW article
Front. Med.
Sec. Hematology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1448654
High altitude polycythemia and its maladaptive mechanisms: an updated review
Provisionally accepted- 1 Other, Chengdu, China
- 2 Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China
High altitude polycythemia is a maladaptation of highlanders exposed to hypoxic environment, leading to high blood viscosity and severe cardiorespiratory dysfunction. Prolonged hypoxia causes respiratory depression and severe hypoxemia, and further mediates changes in genetic and molecular mechanisms that regulate erythropoiesis and apoptosis, ultimately resulting in excessive erythrocytosis (EE). This updated review investigated the maladaptive mechanisms of EE, including respiratory chemoreceptor passivation, sleep-related breathing disorders, sex hormones, iron metabolism, and hypoxia-related factors and pathways.
Keywords: Excessive erythrocytosis, High altitude polycythemia, hypoxemia, maladaptive mechanisms, review
Received: 13 Jun 2024; Accepted: 12 Aug 2024.
Copyright: © 2024 Tang, Zhou, Chen, Yan, Chen and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shijie Tang, Other, Chengdu, China
Wenwen Zhou, Other, Chengdu, China
Ling Chen, Other, Chengdu, China
Hui Yan, Other, Chengdu, China
Lei Chen, Other, Chengdu, China
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