Skip to main content

ORIGINAL RESEARCH article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1447566

Protective effect of Bletilla ochracea Schltr. against acetogenic gastric ulcer in rats based on non-targeted metabolomics

Provisionally accepted
Xiusheng Tang Xiusheng Tang 1*Qi Zeng Qi Zeng 2Rongze Fang Rongze Fang 3
  • 1 The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, China
  • 2 School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China
  • 3 School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China

The final, formatted version of the article will be published soon.

    Background: Gastric ulcer (GU), a globally prevalent disease, represents a significant burden to human health. Bletilla ochracea Schltr. (BOS), an herbal medicine, shows promising therapeutic potential in the treatment of chronic GU.This study utilized a rat model of chronic gastric ulceration induced by acetic acid to evaluate the protective effects of Bletilla ochracea Schltr. (BOS) on gastric tissue through the analysis of gross morphological and histopathological changes. Non-targeted metabolomic techniques were employed to identify differential metabolites, followed by the use of metabolic analysis software to enrich the pathways associated with these metabolites, thereby revealing the potential mechanisms underlying the anti-gastric ulcer effects of BOS.The results suggest that the primary mechanism underlying BOS regulation of GU involves modulation of endogenous metabolites, including dimethylglycine, L-2,4-diaminobutyric acid, uridine propionic acid and L-asparagine. These diverse metabolites may have anti-inflammatory, antioxidant and reparative properties. In addition, KEGG enrichment analysis indicated potential anti-GU effects of BOS through diverse pathways such as energy metabolism, immune metabolism and amino acid metabolism.The study demonstrates BOS protective effects on GU in rats, potentially through modulating key metabolites and pathways, highlighting its therapeutic potential and warranting further investigation for clinical applications.

    Keywords: gastric ulcer, Bletilla ochracea Schltr., non-targeted metabolomics, metabolic pathway, protective effect

    Received: 11 Jun 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Tang, Zeng and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xiusheng Tang, The First Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.