Guojun Tong
Hui Li
*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1447041
This article is part of the Research Topic Tumor Microenvironment and Personalized Therapy of Gastrointestinal Cancer View all 5 articles
The Combined Evaluation of Preoperative Serum CEA and Postoperative Tissue CEA as a Prognostic Factor in Stages 0-Ⅳ Colorectal Cancer: A retrospective Cohort Study
Provisionally accepted- Huzhou Central Hospital, Huzhou, China
The roles of preoperative serum carcinoembryonic antigen (sCEA) and postoperative tissue carcinoembryonic antigen (tCEA) have been extensively studied in isolation in colorectal cancer (CRC). However, the combined role of sCEA and tCEA remains inadequately described.Methods: A total of 1757 retrospective cases of stage 0-IV CRC from January 2006to January 2016 in our institution were included. Clinicopathological features and follow-up data were collected. Stage 0 was combined with stage I. sCEA levels were classified as normal or high (>10 ng/ml), while tCEA levels were categorised into three grades (+, ++, +++). This resulted in six combined groups (2 x 3). ANOVA and cross-tabulation were employed to analyse continuous and categorical data, respectively. Univariate and multivariate analyses were conducted using Cox regression. All data were analysed using SPSS 27 and R 4.3.1.Results: Some clinicopathologic features differed significantly among the combined CEA test groups (all P < 0.05). The ROC (Receiver Operating Characteristic) curves for sCEA, tCEA, and combined CEA exhibited significant differences in five-year OS with death as the input variable (all P < 0.05). The AUC (Area Under the Curve) for combined CEA was the highest, indicating the value of this study. Cox regression analysis demonstrated that tumour location, T stage, differentiation, chemotherapy, TNM stage, tCEA, and combined CEA were significant in the univariate analysis; however, tCEA was not significant (P = 0.096) in the multivariate analysis among these seven variables. Five-year OS analysis revealed that sCEA, tCEA, and combined CEA were not significant in stages 0 & I -II (all P > 0.05) but were significant in stages III-IV (all P < 0.05), except for tCEA in stage IV (P = 0.24) as per K-M and univariate analysis. No significant difference was observed between sCEA and tCEA (P = 0.55, 0.095), whereas combined CEA demonstrated a significant difference (P < 0.001) in both univariate and multivariate analyses.Conclusions: sCEA, tCEA, and combined CEA exhibit prognostic roles in stages III-IV of CRC, with only combined CEA serving as an independent factor in these stages.
Keywords: CRC, prognosis, SCEA, TCEA, combined CEA, ROC, AUC, os
Received: 11 Jun 2024; Accepted: 11 Dec 2024.
Copyright: © 2024 Tong, Li, Shen, Tan and Qian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hui Li, Huzhou Central Hospital, Huzhou, 313003, China
Yan Shen, Huzhou Central Hospital, Huzhou, 313003, China
Zhenhua Tan, Huzhou Central Hospital, Huzhou, 313003, China
Hai Qian, Huzhou Central Hospital, Huzhou, 313003, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.