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ORIGINAL RESEARCH article

Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1446364
This article is part of the Research Topic Road Trip from Mild to Severe Asthmatic Inflammation: The Traffic Lights of Biomarkers in Asthma Management - Volume II View all 4 articles

Association between system inflammation response index and mortality among population with asthma

Provisionally accepted
Feng Xu Feng Xu *Fanglan Li Fanglan Li Yan Wen Yan Wen Pan Jiang Pan Jiang
  • Shenzhen Guangming District People's Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Background: As a novel indicator of inflammation, the relationship between the systemic immune-inflammation index (SIRI) and mortality in patients with asthma remains uncertain. Our study aims to explore the association between SIRI and mortality in asthma patients. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) for US adults from 2001 to 2018 were included in this study. Then we divided all patients into three groups based on SIRI tertiles, and used multivariable weighted Cox regression analysis, smoothing curve fitting, survival curve analysis and subgroup analysis to investigate the relationship between SIRI and asthma. Results: 6,156 participants were included in the study, with each SIRI tertile consisting of 2052 individuals. The asthma patients with higher SIRI levels were older, had a higher level of education, were more likely to be married, and had a higher chance of being smokers. In Cox proportional hazards models, the highest SIRI group showed higher hazard ratios (HRs) for all-cause mortality among individuals with asthma after adjusting for potential confounders. The restricted cubic spline analysis indicated a nonlinear relationship between SIRI and all-cause mortality. Kaplan-Meier survival curves showed patients with higher SIRI levels had higher risk of all-cause mortality. Subgroup analyses revealed SIRI’s association with all-cause mortality across various demographics, including age, sex, race, education levels, smoking status, and marital status. Conclusion: In conclusion, our study provides evidence for the relationship between SIRI and mortality in asthma patients. SIRI may potentially serve as a predictive tool for evaluating asthma mortality rates.

    Keywords: systemic immune-inflammation index, Mortality, Asthma, NHANES, Association

    Received: 09 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Xu, Li, Wen and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Feng Xu, Shenzhen Guangming District People's Hospital, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.