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CASE REPORT article

Front. Med.
Sec. Hematology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1445971

Case Report: Atypical POEMS Syndrome Without Polyneuropathy, complicated by Borderline TAFRO Syndrome

Provisionally accepted
Shuai Tan Shuai Tan 1Mingyue Shang Mingyue Shang 1Yasufumi Masaki Yasufumi Masaki 2Jing Ni Jing Ni 1Yuwei Da Yuwei Da 3Jing Sun Jing Sun 1Yaofang Cao Yaofang Cao 1Li Su Li Su 1Wanling Sun Wanling Sun 1*
  • 1 Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 2 Kanazawa Medical University, Uchinada, Ishikawa, Japan
  • 3 Xuanwu Hospital, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    This case provides valuable information for identifying POEMS syndrome, especially when EMG results of peripheral neuropathy may suggest severe edema. It also highlights a specific rare disease typeatypical POEMS syndrome without polyneuropathy.  The patient, critically ill, presented with multiple rare diseases simultaneously, including POEMS syndrome, TAFRO syndrome, and Castleman disease, offering a valuable opportunity to improve disease identification.  Rapid diagnosis and treatment (using dexamethasone) was crucial in saving the patient's life. Continued improvement in quality of life was observed with ASCT after several courses of chemotherapy using the Rd regimen, and the prognosis remains favorable to date.

    Keywords: POEMS Syndrome, Castleman disease (CD), TAFRO syndrome, peripheral neuropathy, ASCT

    Received: 08 Jun 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Tan, Shang, Masaki, Ni, Da, Sun, Cao, Su and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wanling Sun, Department of Hematology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Beijing Municipality, China

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