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SYSTEMATIC REVIEW article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1445550

Evolutionary patterns and research frontiers in autophagy in podocytopathies: a bibliometric analysis

Provisionally accepted
Feng Liu Feng Liu 1Ziyu Xu Ziyu Xu 1Gaijie Chen Gaijie Chen 2Xiaojing Xu Xiaojing Xu 3Huixia Cao Huixia Cao 1Jiefang Chen Jiefang Chen 4*
  • 1 Department of Nephrology, Henan Provincial People’s Hospital, Zhengzhou, China
  • 2 Department of Health Management, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China
  • 3 Department of Respiratory and Critical Care Medicine, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China
  • 4 Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Podocytopathies are a uniquely renal disease syndrome, in which direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Of the many factors that contribute to podocytopathies, the abnormal regulation of autophagy, such insufficient or excessive autophagy levels, have been proposed to play a significant role in the occurrence and development of podocytopathies. However, there still has been a lack of systematic and comparative research to elucidate exact role of autophagy in podocytopathies and its current research status. Based on the above research background, this study aims to utilize bibliometric analysis to clarify the role of autophagy in the pathogenesis of podocytopathies, analyze the research focus in this area, as well as explore the future research trends. To this end, we retrieved original articles and review papers with respect to autophagy in podocytopathies research published between the year 2008 and 2022 from the Web of Science Core Collection (WOSCC). Then, VOSviewer and CiteSpace software were employed to reveal the leading subjects and generate visual maps of countries/regions, organizations, authors, journals, and keyword networks in this field. China, the United States and Japan are the main drivers, while Professor Koya Daisuke, Professor He Qiang, and Professor Jin Juan are the most prolific researcheres in this field. Oxidative stress, the NLRP3 inflammasome, and therapeutic targets were the knowledge base for the research in this special field. Taken together, this bibliometric analysis helps us reveal the current research hotspots and guide future research directions, which provides a reference for scholars to further investigate the role of autophagy in podocytopathies as well as conduct clinical trial with autophagy regulators in podocytopathies.

    Keywords: bibliometric analysis, podocytopathies, Autophagy, Visualization analysis, Web of Science Core Collection

    Received: 07 Jun 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 Liu, Xu, Chen, Xu, Cao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiefang Chen, Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou, 45003, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.