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ORIGINAL RESEARCH article

Front. Med.
Sec. Nephrology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1445487
This article is part of the Research Topic Cell Cross-Talk in Diabetic Kidney Diseases, Volume III View all articles

Association between serum vitamin D and the risk of diabetic kidney disease in patients with type 2 diabetes

Provisionally accepted
Yujie Wang Yujie Wang 1*Chenggang Hu Chenggang Hu 2Ying Li Ying Li 1Qi Liu Qi Liu 1Lichao Gao Lichao Gao 1Dongmei Zhang Dongmei Zhang 1Cao Ling Cao Ling 1
  • 1 The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • 2 Sino-Portugal TCM International Cooperation Center, Affiliated Traditional Chinese Medicine Hospital , Southwest Medical University, Longmatan, Liaoning, China

The final, formatted version of the article will be published soon.

    Aims: This investigation explored the potential correlation between serum vitamin D concentration and diabetic kidney disease (DKD) among patients with type 2 diabetes mellitus (T2DM).Methods: This cross-sectional study assessed 4,570 patients with T2DM drawn from the National Health and Nutrition Examination Survey (NHANES) dataset. Restricted cubic splines were utilized to examine the dose-response relationship between serum vitamin D levels and the risk of DKD in patients with T2DM. Serum vitamin D concentrations were divided into quartiles for multivariable logistic regression analysis to evaluate the association between varying serum vitamin D levels and DKD risk in patients with T2DM. Additionally, sex-stratified analyses were conducted to determine consistency of the results. The influence of vitamin D concentrations on mortality risk was assessed using a Cox regression model.Results: Of the patients with T2DM, 33% were diagnosed with DKD. Restricted cubic spline plots revealed a U-shaped relationship between vitamin D levels and DKD risk, with a protective effect noted in the mid-range, indicating optimal serum vitamin D concentrations between 59.6 nmol/L and 84.3 nmol/L. The multivariate Cox regression analysis suggested that higher VID levels were associated with a reduced mortality risk, particularly in male patients.The regulation and monitoring of serum vitamin D levels within an optimal range may play a pivotal role in the prevention of DKD in patients with T2DM. Public health strategies should emphasize the regular monitoring of vitamin D levels, especially among populations at elevated risk, to mitigate the progression of DKD and decrease the associated mortality rates.

    Keywords: Diabetic kidney disease, type 2 diabetes mellitus, Vitamin D, Mortality, non-linear relationship

    Received: 07 Jun 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Wang, Hu, Li, Liu, Gao, Zhang and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yujie Wang, The Affiliated Hospital of Southwest Medical University, Luzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.