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ORIGINAL RESEARCH article

Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1444481

Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study Running head: The relationship between platelet and 30-day in-hospital mortality

Provisionally accepted
Zhe Deng Zhe Deng 1Pan Zhou Pan Zhou 2Xin Li Xin Li 2Li Zhou Li Zhou 2Zhe Deng Zhe Deng 2*
  • 1 Shenzhen Baoan People's Hospital, Shenzhen, China
  • 2 Departemnt of Emergency Medicine , Shenzhen Second People’s Hospital / the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China

The final, formatted version of the article will be published soon.

    Background: The relationship between platelet count and sepsis outcomes in intensive care units (ICUs) requires comprehensive investigation through large-scale multicenter studies.In this multicenter retrospective cohort study, we analyzed 17,977 sepsis patients from 208 U.S. hospitals (2014)(2015) using the eICU Collaborative Research Database v2.0. Analyses were adjusted for demographics, clinical parameters, comorbidities, and treatments. Generalized additive models and two-piecewise linear regression were used to assess the relationship between platelet count and mortality.Results: A U-shaped relationship was identified with an inflection point at 176×10⁹/L. Below this threshold, each 10×10⁹/L increase in platelet count was associated with a 6% decrease in mortality risk (adjusted OR 0.94, 95% CI 0.93-0.95, p<0.0001), while above it, each 10×10⁹/L increase was associated with a 1% increase in mortality risk (adjusted OR 1.01, 95% CI 1.00-1.01, p=0.0153).This large-scale, multicenter retrospective study has made a significant contribution to understanding the association between platelet count and mortality in patients with sepsis in intensive care units. We identified a critical threshold of 176×10 9 /L for platelet count and demonstrated a distinct U-shaped relationship with 30-day in-hospital mortality, providing valuable reference criteria for clinical risk stratification.

    Keywords: Platelet, Sepsis, 30-day in-hospital mortality, nonlinear, Multicenter study

    Received: 05 Jun 2024; Accepted: 19 Dec 2024.

    Copyright: © 2024 Deng, Zhou, Li, Zhou and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhe Deng, Departemnt of Emergency Medicine , Shenzhen Second People’s Hospital / the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.