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REVIEW article

Front. Med.
Sec. Ophthalmology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1439888
This article is part of the Research Topic Reviews in: Ophthalmology 2024 View all articles

The involvement of Aquaporin 5 in the inflammatory response of primary Sjogren's syndrome dry eye: potential therapeutic targets exploration

Provisionally accepted
Lijuan Fu Lijuan Fu 1Zihang Zhao Zihang Zhao 2*Shuang Zhao Shuang Zhao 1*Meiying Zhang Meiying Zhang 1*Xiaoming Teng Xiaoming Teng 1*Tiansong Yang Tiansong Yang 1*
  • 1 Heilongjiang University of Chinese Medicine, Harbin, China
  • 2 China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Sjogren's syndrome (SS) is a chronic autoimmune disease. Mainly due to the infiltration of lymphoplasmic cells into the exocrine glands, especially the salivary glands and lacrimal glands, resulting in reduced tear and saliva secretion. Reduced tear flow can trigger Sjogren's syndrome dry eye (SSDE). Although the pathophysiology of SSDE xerosis remains incompletely understood, recent advances have identified aquaporin-5 (AQP5) as a critical factor in dysregulation of the exocrine gland and epithelium, influencing the clinical presentation of SSDE through modulation of inflammatory microenvironment and tear secretion processes. This review aims to explore AQP5 regulatory mechanisms in SSDE and analyze its potential as a therapeutic target, providing new directions for SSDE treatment.

    Keywords: Aquaporin-5, Sjogren's syndrome dry eye, Inflammatory Response, Therapeutic target, lacrimal gland

    Received: 28 May 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Fu, Zhao, Zhao, Zhang, Teng and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zihang Zhao, China Academy of Chinese Medical Sciences, Beijing, 100700, Beijing Municipality, China
    Shuang Zhao, Heilongjiang University of Chinese Medicine, Harbin, China
    Meiying Zhang, Heilongjiang University of Chinese Medicine, Harbin, China
    Xiaoming Teng, Heilongjiang University of Chinese Medicine, Harbin, China
    Tiansong Yang, Heilongjiang University of Chinese Medicine, Harbin, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.