AUTHOR=Zhu Lili , Jiang Xiaohong 

TITLE=Characteristics of blood lipid and metabolic indicators in subclinical hypothyroidism patients: a retrospective study

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1439626

DOI=10.3389/fmed.2024.1439626

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>The characteristics of blood lipid and metabolic indicators were analyzed in patients with subclinical hypothyroidism (SCH), and the effect of type 2 diabetes mellitus (T2DM) on SCH patients was determined.</p></sec><sec id="sec2"><title>Methods</title><p>The physical examination data of 2,119 residents in a university community were retrospectively divided into 2 groups (SCH and non-SCH groups). Furthermore, the SCH group was divided into SCH-T2DM and SCH–non-T2DM subgroups, and the data between the groups were analyzed.</p></sec><sec id="sec3"><title>Results</title><p>The SCH group had significantly higher levels of triglycerides (<italic>p</italic> = 0.044), total cholesterol (<italic>p</italic> = 0.001), low-density lipoprotein cholesterol (<italic>p</italic> = 0.019), very low-density lipoprotein cholesterol (<italic>p</italic> = 0.044), 2-h plasma glucose (<italic>p</italic> = 0.023), and globulin (<italic>p</italic> = 0.000) compared to the non-SCH group. The SCH–T2DM group was older (<italic>p</italic> &lt; 0.001), had a greater BMI (<italic>p</italic> = 0.028), a more rapid heart rate (<italic>p</italic> = 0.025), and a greater waist circumference (<italic>p</italic> &lt; 0.001) than the SCH–non-T2DM group based on the subgroup analysis. The SCH–T2DM group had significantly higher dyslipidemia and dysglycemia levels than the SCH–non-T2DM group.</p></sec><sec id="sec4"><title>Conclusion</title><p>Patients with SCH with or without T2DM may have dyslipidemia and dysglycemia and should be evaluated accordingly.</p></sec>