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SYSTEMATIC REVIEW article

Front. Med.
Sec. Rheumatology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1439182

Mitochondria: a breakthrough in combating rheumatoid arthritis

Provisionally accepted
Shuang Li Shuang Li *Anting Liu Anting Liu *Chenlu Huo Chenlu Huo *Yan Zhu Yan Zhu *
  • Anhui University of Chinese Medicine, Hefei, China

The final, formatted version of the article will be published soon.

    As a chronic autoimmune disease with complex aetiology, rheumatoid arthritis (RA) has been demonstrated to be associated with mitochondrial dysfunction since mitochondrial dysfunction can affect the survival, activation, and differentiation of immune and non-immune cells involved in the pathogenesis of RA. Nevertheless, the mechanism behind mitochondrial dysfunction in RA remains uncertain. Accordingly, this review addresses the possible role and mechanisms of mitochondrial dysfunction in RA and discusses the potential and challenges of mitochondria as a potential therapeutic strategy for RA, thereby providing a breakthrough point in the prevention and treatment of RA.

    Keywords: Mitochondria, Mitochondrial dysfunction, Rheumatoid arthritis, Breakthrough point, Synthesis

    Received: 27 May 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Li, Liu, Huo and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shuang Li, Anhui University of Chinese Medicine, Hefei, China
    Anting Liu, Anhui University of Chinese Medicine, Hefei, China
    Chenlu Huo, Anhui University of Chinese Medicine, Hefei, China
    Yan Zhu, Anhui University of Chinese Medicine, Hefei, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.