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CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1437650
Case report: Recurrence of primary hepatic neuroendocrine tumors after resection of liver segments IV in 8 years follow-up
Provisionally accepted- 1 The Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
- 2 Department of Pathology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
- 3 Medical Imaging Department, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, China
- 4 Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China, KunMing, China
Background: Primary hepatic neuroendocrine tumors (PHNETs) are an utterly rare entity. The diagnosis of PHNETs could legitimize when an extrahepatic primary NET must always be excluded. PHNETs can achieve a high survival rate after complete surgical resection, however, most patients still have an 18% risk of recurrence within 5 years after surgery. In our case, the recurrence occurred 8 years after the first hepatectomy, which is relatively rare in the current literature. Therefore, rigorous postoperative follow-up is necessary for early detection and timely treatment of recurrent PHNETs.We report a case of PHNET in a 24-year-old previously healthy female patient who relapsed 8 years after hepatectomy. This case focuses on the importance of diagnosis of primary and recurrent PHNETS in young patients, rare pathological types, and post-operative follow-up.This case report detailed the rare pathological morphology and characteristic immunohistochemical markers in our case for PHNETS, which enhanced the new understanding of the diagnosis of this entity. In addition, we also highlighted the variable duration of recurrence after treatment of PHNETs. The 8-year recurrent period in our case suggests the importance of regular examination in patients with PHNETs by following the doctor's instructions.
Keywords: Neuroendocrine Tumors, Liver, follow-up, Recurrence, case report
Received: 05 Jun 2024; Accepted: 02 Sep 2024.
Copyright: © 2024 Li, Bian, Fan, Huang, Li and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bo He, The Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
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