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ORIGINAL RESEARCH article

Front. Med.
Sec. Precision Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1437376

Safety Analysis of Quinolones Use in Minors-Based on the FAERS Database

Provisionally accepted
Yanwei Li Yanwei Li 1Jing Wang Jing Wang 2*ChengLiang Wang ChengLiang Wang 1Li Chen Li Chen 3,4,5*
  • 1 People's Hospital of Ganzi Tibetan Autonomous Prefecture, Kangding, Sichuan, China
  • 2 Sichuan Mianyang 404 Hospital, Mianyang, China
  • 3 Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 4 Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 5 Department of Pharmacology, Faculty of Medicine and Nursing. University of the Basque Country, Leioa, Basque Country, Spain

The final, formatted version of the article will be published soon.

    Objective: This study utilizes the FDA Adverse Event Reporting System (FAERS) to investigate adverse drug event (ADE) signals linked to quinolones use (ciprofloxacin, moxifloxacin, levofloxacin, ofloxacin) in minors, offering insights for clinical use.Methods: Minors were categorized into four age groups. ADE reports for these quinolones from the first quarter of 2015 to the third quarter of 2023 were extracted from the FAERS database. Data analysis used reporting odds ratio (ROR) and the MHRA method.Results: Most ADE cases in minors involved ciprofloxacin(575)and levofloxacin (477). In the infant group, various injury, poisoning, and procedural complication events were more frequently associated with ciprofloxacin, levofloxacin, and moxifloxacin (19.83%, 31.25%, and 100.00%, respectively). In the preschool children group, psychiatric disorders were more frequently reported with levofloxacin and ofloxacin use (59.00% and 47.62%, respectively). Ocular disorders were notably associated with moxifloxacin in the children group (62.50%), In the adolescent group, more gastrointestinal diseases occurred with ciprofloxacin (12.96%).: ADE occurrence with quinolones in minors varies by age. Strict adherence to indications, rational use, avoiding prolonged use, and monitoring for short-term reactions are essential. Enhanced monitoring of interactions and drug education are crucial to reducing ADE.

    Keywords: FAERS, Minors, Quinolones, Safety analysis, Reporting Odds Ratio method, proportional imbalance method

    Received: 23 May 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Li, Wang, Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jing Wang, Sichuan Mianyang 404 Hospital, Mianyang, China
    Li Chen, Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, 610041, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.