Wangxing Huang
1
Zhipeng Hu
2*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1436753
This article is part of the Research Topic Gastrointestinal Tract Infections: A Global Perspective View all 12 articles
Efficacy of Percutaneous Microwave Ablation Guided by Contrast-enhanced and Two-dimensional Ultrasound for in Hepatic Alveolar Echinococcosis in Difficult/Dangerous Locations
Provisionally accepted- 1 Graduate School of Qinghai University, Xining, China
- 2 Other, Xining, China
- 3 Other, Beijing, China
Background: Ultrasound-guided microwave ablation (MWA) has become a popular method for treating malignant liver tumors. However, few studies have investigated its use in the treatment of hepatoalveolar echinococcosis (HAE). This study aimed to explore the effectiveness and safety of contrast-enhanced ultrasound combined with two-dimensional ultrasound-guided MWA for the treatment of HAE in difficult/dangerous locations.Methods: Data from 81 patients, who were diagnosed with hepatic alveolar hydatid disease in difficult/dangerous locations between January 2018 and January 2023, and underwent contrastenhanced ultrasonography combined with two-dimensional ultrasound-guided MWA, were analyzed.After undergoing MWA, patients were followed up to determine whether the lesions recurred and to evaluate the therapeutic effect of MWA. Preoperatively, individualized strategies were designed for lesions in different locations, and different auxiliary ablation technologies were used for contrast- enhanced ultrasound combined with two-dimensional ultrasound-guided MWA to achieve complete inactivation of lesions in difficult/dangerous locations.Results: MWA was performed on 89 HAE lesions in 81 patients. The median diameter of the lesions was 2.86 cm (interquartile range [IQR] 2.36-3.49 cm). The complete ablation rate after surgery was 100%, with a recurrence rate of 11.11%, and median follow-up of 24 months (IQR 12-48 months). The incidence of minor complications was 14.8%; no serious complications or deaths occurred. Compared with before surgery, albumin, TB, DB, alanine aminotransferase, and aspartate aminotransferase levels increased (p<0.001), platelets and activated partial thromboplastin time decreased (p<0.001), with no statistical difference in prothrombin time (p>0.05).Conclusions: MWA may be a safe and effective method for treating HAE in difficult/dangerous locations, and may represent a new and alternative option for this patient population.
Keywords: Alveolar echinococcosis, Multilocular echinococcosis, Hepatic alveolar echinococcosis, Microwave ablation, Contrast-enhanced and two-dimensional ultrasound
Received: 31 May 2024; Accepted: 29 Jul 2024.
Copyright: © 2024 Huang, Hu, Qi, Zhang, Li, Yu and Hua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhipeng Hu, Other, Xining, China
Lina Qi, Other, Xining, China
Xiaoyan Zhang, Other, Xining, China
Min Li, Other, Xining, China
Mingan Yu, Other, Beijing, China
Guoyong Hua, Other, Xining, China
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