Qiang He
1,2*
Zhen Wang
3
Chengxin Xie
4
Xin Sun
1*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Med.
Sec. Family Medicine and Primary Care
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1433846
This article is part of the Research Topic New Frameworks for Chronic Diseases Treatment: Research, Prevention, Intervention View all 4 articles
Relationship between systemic immune-inflammation index and Osteoarthritis: A Cross-sectional Study from the NHANES 2005-2018
Provisionally accepted- 1 Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
- 2 Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
- 3 QiQiHaEr City Traditional Chinese Medicine Hospital, QiQiHaEr, China
- 4 Shandong First Medical University, Tai'an, Shandong, China
Objective: The study aimed to explore the relationship between systemic inflammatory response index (SIRI) levels and osteoarthritis (OA) using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) database from 2005 to 2018. Methods: Using cross-sectional data from the NHANES database from 2005 to 2018, we included 11,381 study participants divided into OA (n=1,437) and non-OA (n=9,944) groups. Weighted multivariable regression models and subgroup analyses were employed to investigate the relationship between SIRI and OA. Additionally, restricted cubic spline models were used to explore nonlinear relationships. Results: This study enrolled 11,381 participants aged ≥20 years, including 1,437 (14%) with OA. Weighted multivariable regression analysis in the fully adjusted Model 3 indicated a correlation between higher levels of SIRI (log2-transformed) and an increased OA risk (odds ratio: 1.150; 95% confidence interval: 1.000–1.323, P<0.05). Interaction tests showed that the variables did not significantly affect this correlation (P for interaction all >0.05). Additionally, a restricted cubic spline model revealed a nonlinear relationship between log2(SIRI) and OA risk, with a threshold effect showing 4.757 as the critical value of SIRI. SIRI <4.757 showed almost unchanged OA risk, whereas SIRI >4.757 showed rapidly increasing OA risk. Conclusion: The positive correlation between SIRI and OA risk, with a critical value of 4.757, holds clinical value in practical applications. Additionally, our study indicates that SIRI is a novel, clinically valuable, and convenient inflammatory biomarker that can be used to predict OA risk in adults.
Keywords: systemic immune-inflammation index, Osteoarthritis, NHANES, relationship, a cross-sectional study
Received: 16 May 2024; Accepted: 29 Jul 2024.
Copyright: © 2024 He, Wang, Mei, Xie and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qiang He, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China
Xin Sun, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China
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