Xin-Feng Zhang
Xiao Li Zhang
Li Guo
*
Yan Tian
*The final, formatted version of the article will be published soon.
REVIEW article
Front. Med.
Sec. Gene and Cell Therapy
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1432224
The function of the inter-alpha-trypsin inhibitors in the development of disease
Provisionally accepted- The First Affiliated Hospital of Kunming Medical University, Kunming, China
Through the formation of covalent connections with hyaluronic acid (HA), the Inter-α-trypsin inhibitor (IαI) family collaborates to preserve the stability of the extracellular matrix (ECM). The five distinct homologous heavy chains (ITIH) and one type of light chain make up the IαI family. ITIH alone or in combination with bikunin (BK) has been proven to have important impacts in a number of earlier investigations. This implies that BK and ITIH might be crucial to both physiological and pathological processes. The functions of BK and ITIH in various pathophysiological processes are discussed independently in this paper. In the meanwhile, this study offers suggestions for further research on the roles of BK and ITIH in the course of disease and summarizes the plausible mechanisms of the previous studies.
Keywords: Inter-α-trypsin inhibitor (IαI) family, bikunin (BK), ITIHs, Hyaluronic Acid, Extracellular Matrix (ECM)
Received: 13 May 2024; Accepted: 15 Jul 2024.
Copyright: © 2024 Zhang, Zhang, Guo, Bai, Tian and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Li Guo, The First Affiliated Hospital of Kunming Medical University, Kunming, China
Yun-Ping Bai, The First Affiliated Hospital of Kunming Medical University, Kunming, China
Yan Tian, The First Affiliated Hospital of Kunming Medical University, Kunming, China
Hua-You Luo, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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