AUTHOR=Luis-Silva Fabio , Menegueti Mayra Gonçalves , Peres Leandro Moreira , Sepeda Corina dos Reis , Jordani Maria Cecília , Mestriner Fabiola , Petroski-Moraes Bruno Cesar , Brito-de-Sousa Joaquim Pedro , Costa-Rocha Ismael Artur , Cruz Bruna Lemos , Donadel Mariana Dermínio , de Souza Felipe Barizza , Reis Gustavo Henrique Martins , Bellissimo-Rodrigues Fernando , Basile-Filho Anibal , Becari Christiane , Evora Paulo Roberto Barbosa , Martins-Filho Olindo Assis , Auxiliadora-Martins Maria TITLE=Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial JOURNAL=Frontiers in Medicine VOLUME=11 YEAR=2024 URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1431321 DOI=10.3389/fmed.2024.1431321 ISSN=2296-858X ABSTRACT=Purpose

Methylene blue (MB) has been used to increase blood pressure in patients with septic shock by acting on guanylate cyclase and nitric oxide synthase.

Objective

To determine whether the administration of MB to patients in the initial phase of septic shock leads to a reduction in the use of vasopressors compared to the Control group.

Methods

This was a 1:1 randomized clinical trial of two groups (MB and Control). Forty-two patients were included in the present study; 23 patients were allocated to the Control group, and 19 were randomized to the MB group. Both groups had access to standard treatment, consisting of fluid replacement, vasopressors, and antibiotic therapy. Patients received a loading dose of MB (3 mg/kg) and maintenance (0.5 mg/kg/h) for 48 h. Vasopressor doses, laboratory test results, inflammatory and anti-inflammatory cytokine levels, and hemodynamic monitoring were recorded before the infusion of MB (T1) and after 20 min (T2), 2 h (T3), 24 h (T4), 48 h after the infusion started (T5) and 24 h after weaning (T6).

Results

MB therapy was started together with the indication of vasopressin (VAS) as a second vasopressor. The MB group showed an immediate reduction in NOR dosage, an earlier reduction in VAS dosage, and higher IL-10 levels compared to the Control group.

Conclusion

Early administration of MB in combination with standard treatment for septic shock might be reduce vasopressors dose. Continuous infusion of MB for 48 h was considered safe and there was no adverse events. These results highlight the potential of MB as a safe adjuvant therapeutic option in the treatment of septic shock.

Clinical trial registration

https://clinicaltrials.gov/, identifier RBR-96584w4.