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CLINICAL TRIAL article

Front. Med.
Sec. Hepatobiliary Diseases
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1429546
This article is part of the Research Topic Diagnosis and Management of Acute, Chronic, and Autoimmune Pancreatitis View all 8 articles

Efficacy of Integrated Traditional Chinese and Western Medicine in Managing Mild-Moderate Acute Pancreatitis: A Real-World Clinical Perspective Analysis

Provisionally accepted
Sailei Jia Sailei Jia 1Qian Chen Qian Chen 1*Xitong Liu Xitong Liu 1*Yanhong Li Yanhong Li 2*Lihui Wang Lihui Wang 1*Shixiang Hu Shixiang Hu 1*Xian Li Xian Li 1*
  • 1 Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China
  • 2 Huanghe University of Science and Technology, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Background: Given the prevalent utilization of integrated traditional Chinese and western medicine (ITCWM) in the management of acute pancreatitis, the majority of studies have concentrated on severe cases, lacking robust evidence-based medical research. Consequently, relying on real-world research, we intend to evaluate the clinical efficacy and safety of the combined approach in treating mild to moderate acute pancreatitis. Methods: A total of 563 AP patients from Henan Central Hospital were collected from January 2019 to October 2023. A propensity score matching (PSM) analysis was conducted to evaluate the clinical efficacy of traditional Chinese medicine (TCM) in treating mild to moderate acute pancreatitis. Patients were divided into a control group (61 cases) and an integrated traditional Chinese and Western medicine (ITCWM) group (120 cases). To further assess the clinical efficacy of TCM enema in the treatment of mild to moderate acute pancreatitis, PSM analysis was conducted across three groups. The patients were categorized into a control group (n=49), an oral TCM treatment group (OCM group, n=274), and an oral TCM plus enema treatment group (OCM+E group, n=131). Logistic regression was used to analyze factors after treatment in each group, and the Kaplan-Meier method compared symptom duration in each group. Results: Compared with the control group, the ITCWM group significantly decreased C-reactive protein (CRP, mg/L) (17.8[1.2-59.5] vs. 8.0[3.3-33.5], P=0.022), shortened the duration of abdominal distension, abdominal pain, nausea and bitter taste symptoms (P<0.05), and shortened the length of hospital stay (median 19.0 and 11.5 days, respectively, P=0.001); Compared with the other two groups, the neutrophil percentage (NEUT%) was lower (74.1 vs. 61.9 vs. 59.5, P<0.05) and serum prealbumin (PA, mg/L) was higher (116.0 vs. 184.4 vs. 220.0, P< 0.05), the length of hospitalization (days) was shortened (19.0 vs.12.0 vs.10.0, P<0.05) in the OCM+E group. Conclusion: The combination of traditional Chinese medicine and modern medicine has been shown to effectively decrease inflammatory indicators in patients with mild to moderate acute pancreatitis, leading to a reduction in symptom duration and hospitalization period, as well as promoting disease recovery. Notably, the use of traditional Chinese medicine in conjunction with enema therapy yields more pronounced benefits.

    Keywords: Integrated traditional Chinese and western medicine, acute pancreatitis, real-word study, mild-moderate pancreatitis, Herbal enema

    Received: 08 May 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Jia, Chen, Liu, Li, Wang, Hu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qian Chen, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China
    Xitong Liu, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China
    Yanhong Li, Huanghe University of Science and Technology, Zhengzhou, 130012, Henan Province, China
    Lihui Wang, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China
    Shixiang Hu, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China
    Xian Li, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.