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REVIEW article

Front. Med.
Sec. Gastroenterology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1429133
This article is part of the Research Topic Gut Microbiota and Gastrointestinal Disorders - Volume II View all 8 articles

Gut microbiota and Irritable bowel syndrome:status and prospect

Provisionally accepted
Xinyu Cheng Xinyu Cheng Yufeng Jiang Yufeng Jiang Zhou Yafeng Zhou Yafeng *
  • Suzhou Dushu Lake Hospital, Suzhou, China

The final, formatted version of the article will be published soon.

    Irritable bowel syndrome (IBS) is a very common gastrointestinal disease that, although not as aggressive as tumors, affects patients' quality of life in different ways.The cause of IBS is still unclear,but more and more studies have shown that the characteristics of the gut microbiota, such as diversity, abundance, and composition, are altered in patients with IBS, compared to the healthy population, which confirms that the gut microbiota plays a crucial role in the development of IBS. This paper aims to identify the commonalities by reviewing a large body of literature. Changes in the characteristics of gut microbiota in patients with different types of IBS are discussed, relevant mechanisms are described, and the treatment modalities of gut microbiota in IBS are summarized. Although there are more clinical trials that have made good progress, more standardized, more generalized, larger-scale, multi-omics clinical studies are what is missing. Overall, gut microbiota plays a crucial role in the development of IBS, and there is even more potential for treating IBS by modulating gut microbiota.

    Keywords: Irritable Bowel Syndrome, Gut Microbiota, gut-brain axis, fecal microbiota transplantation, Brain-gut-microbiome

    Received: 07 May 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Cheng, Jiang and Yafeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Zhou Yafeng, Suzhou Dushu Lake Hospital, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.