AUTHOR=Aldarsooni Maram , Alfarah Mohammad , Albohammod Fatimah , Al-Jaroudi Dania 

TITLE=Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection or in vitro fertilization cycles

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2025

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1429033

DOI=10.3389/fmed.2024.1429033

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Background</title><p>A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12 and 25% has been commonly reported. However, there is still a lack of consensus on whether premature LH surge affects pregnancy outcomes.</p></sec><sec id="sec2"><title>Objective</title><p>This study aimed to evaluate the effect of premature LH surge on pregnancy rates in women with and without premature LH surge during intracytoplasmic sperm injection or stimulation of <italic>in vitro</italic> fertilization cycles at a tertiary hospital in Riyadh, Saudi Arabia.</p></sec><sec id="sec3"><title>Materials and methods</title><p>A cross-sectional study was conducted. Information related to 771 women who had IVF/ICSI cycles between January 2022 and December 2022 was reviewed. Patients were divided into two groups based on premature LH surge.</p></sec><sec id="sec4"><title>Results</title><p>There was no significant difference in patients’ characteristics. The live birth rates were significantly higher in women without premature LH surge than in women with LH surge (12.9% vs. 5.6%) (<italic>p</italic> = 0.010). With regard to the number of oocytes collected, M2, and fertilization rate, these were significantly higher in women without premature LH surge, with <italic>p-</italic>values of 0.001, 0.002, and 0.004, respectively.</p></sec><sec id="sec5"><title>Conclusion</title><p>The study demonstrates significantly higher live birth rates in women without premature LH surge.</p></sec>