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ORIGINAL RESEARCH article

Front. Med.
Sec. Obstetrics and Gynecology
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1429033

Effect of premature luteinizing hormone surge on pregnancy outcomes in intracytoplasmic sperm injection or in-vitro fertilization cycles

Provisionally accepted
Dania Jaroudi Dania Jaroudi maram aldarsooni maram aldarsooni *Mohammed alfara Mohammed alfara *Fattimah Albohammod Fattimah Albohammod *
  • Research Center, King Fahad Medical City, Riyadh, Saudi Arabia

The final, formatted version of the article will be published soon.

    Background: A premature surge in luteinizing hormone (LH) during ovarian stimulation cycles between 12% to 25% has been commonly reported. However, there is still a lack of consensus whether premature LH surge affects pregnancy outcomes.Objective: To evaluate the effect of premature LH surge on pregnancy rate in women with and without premature LH surge during intracytoplasmic sperm injection or in-vitro fertilization cycles stimulation at a tertiary hospital in Riyadh, Saudi Arabia.A cross-sectional study was conducted. Information related to 771 women who had IVF/ICSI cycles between January 2022 till December 2022 was reviewed. The patients were divided into two groups based on premature LH surge.Results: There was no significant difference in the patient's characteristics. Live birth was significantly higher in the women without premature LH surge compared to women with LH surge (12.9% vs. 5.6%) (p=0.010). With regard to the number of oocytes collected, M2 and fertilization rate, it was significantly higher in the women without premature LH surge p-value 0.001, 0.002, 0.004, respectively).The study demonstrates significantly higher live birth rate in the women without premature LH surge.

    Keywords: LH surge, Cetrolix, Pregnancy, in-vitro fertilization cycles, Intracytoplasmic sperm injection

    Received: 07 May 2024; Accepted: 10 Oct 2024.

    Copyright: © 2024 Jaroudi, aldarsooni, alfara and Albohammod. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    maram aldarsooni, Research Center, King Fahad Medical City, Riyadh, Saudi Arabia
    Mohammed alfara, Research Center, King Fahad Medical City, Riyadh, Saudi Arabia
    Fattimah Albohammod, Research Center, King Fahad Medical City, Riyadh, Saudi Arabia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.